Protein Info for PS417_13200 in Pseudomonas simiae WCS417
Annotation: isochorismate synthase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K01851, salicylate biosynthesis isochorismate synthase [EC: 5.4.4.2] (inferred from 48% identity to bps:BPSS0581)Predicted SEED Role
"Isochorismate synthase (EC 5.4.4.2) @ Menaquinone-specific isochorismate synthase (EC 5.4.4.2)" (EC 5.4.4.2)
MetaCyc Pathways
- superpathway of chorismate metabolism (44/59 steps found)
- salicylate biosynthesis I (2/2 steps found)
- 2,3-dihydroxybenzoate biosynthesis (2/3 steps found)
- salicylate biosynthesis II (2/3 steps found)
- 2-carboxy-1,4-naphthoquinol biosynthesis (3/7 steps found)
- superpathway of menaquinol-8 biosynthesis I (5/10 steps found)
- superpathway of demethylmenaquinol-8 biosynthesis I (4/9 steps found)
- enterobactin biosynthesis (5/11 steps found)
- superpathway of menaquinol-10 biosynthesis (4/10 steps found)
- superpathway of menaquinol-11 biosynthesis (4/10 steps found)
- superpathway of menaquinol-12 biosynthesis (4/10 steps found)
- superpathway of menaquinol-13 biosynthesis (4/10 steps found)
- superpathway of menaquinol-6 biosynthesis (4/10 steps found)
- superpathway of menaquinol-7 biosynthesis (4/10 steps found)
- superpathway of menaquinol-9 biosynthesis (4/10 steps found)
- superpathway of demethylmenaquinol-6 biosynthesis I (3/9 steps found)
- superpathway of demethylmenaquinol-9 biosynthesis (3/9 steps found)
- vibriobactin biosynthesis (2/9 steps found)
- bacillibactin biosynthesis (4/12 steps found)
- superpathway of phylloquinol biosynthesis (4/15 steps found)
KEGG Metabolic Maps
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Biosynthesis of siderophore group nonribosomal peptides
- Ubiquinone and menaquinone biosynthesis
Isozymes
No predicted isozymesUse Curated BLAST to search for 5.4.4.2
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A1N7U9H6 at UniProt or InterPro
Protein Sequence (455 amino acids)
>PS417_13200 isochorismate synthase (Pseudomonas simiae WCS417) MNENALLKVFQTAHQRAVAYQRPVMAVSSYAAPTLEALALYEAHRQGFFWCTHSPDLALF GLGCAWQIEASGPRRMLDVDRQWFALCADAVIVGSKAPLLLGGMRFDEQRPCAPHWAAFA DASFHLAHWLLSEDAHGRWLRCQRVVGPDSDPQALARDSLAAYAQLLNPPAATATAPDVI ERIALPSRQWQGKVDRALQAISAGDLNKVVLARHIEYQLDASLDSGAVMQRLHARSNASH LFALHRGEHCFMGATPERLLSCQEGRLTTHALAGSARRGMTANEDHAIGERLLADPKEQH EHRLVVQTITQALDGKVSDLQAASSPHLLKLANVQHLSTPIMAQLNSDKRLLDGIHALHP TPAVGGLPTATAMDFIRRHEGFDRGWYAAPVGWLDSQGNGDFLVALRSALIAPRHCHLFA GCGIVEGSQPAEEYEETQIKLASMEQALLLVPPRP