Protein Info for GFF2576 in Sphingobium sp. HT1-2

Annotation: Permease of the drug/metabolite transporter (DMT) superfamily

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 455 transmembrane" amino acids 26 to 47 (22 residues), see Phobius details amino acids 77 to 99 (23 residues), see Phobius details amino acids 105 to 126 (22 residues), see Phobius details amino acids 159 to 178 (20 residues), see Phobius details amino acids 198 to 219 (22 residues), see Phobius details amino acids 231 to 259 (29 residues), see Phobius details amino acids 269 to 293 (25 residues), see Phobius details amino acids 310 to 336 (27 residues), see Phobius details amino acids 356 to 380 (25 residues), see Phobius details amino acids 397 to 418 (22 residues), see Phobius details amino acids 424 to 440 (17 residues), see Phobius details TIGR00835: amino acid carrier protein" amino acids 31 to 450 (420 residues), 300.4 bits, see alignment E=1e-93 PF01235: Na_Ala_symp" amino acids 67 to 453 (387 residues), 302.5 bits, see alignment E=3e-94

Best Hits

KEGG orthology group: K03310, alanine or glycine:cation symporter, AGCS family (inferred from 89% identity to sjp:SJA_C1-27470)

Predicted SEED Role

"Permease of the drug/metabolite transporter (DMT) superfamily" in subsystem Queuosine-Archaeosine Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (455 amino acids)

>GFF2576 Permease of the drug/metabolite transporter (DMT) superfamily (Sphingobium sp. HT1-2)
MENFNAAVDALSSAVFFKVPLFGAQIELIVLYLALPMLFFTIWLGFPNVTQVGRAIRILR
SQPHEGEAKGDVSQWGALSTALSGTIGLGNIAGVAVALTMGGPGAILWMFIIGWFAMTVK
MAEVTLGLKYRVFDERGHVHGGPMYVLKAVGAARGWPKVGLVLGGAYAFFALFGAIPMVQ
VNQSFAQVKVVTGMTNGWAYGVFIAAAVALVTMGGAAWLGEVSKRLTPLKVTVYLGGVAA
ILILHADAIPGALALIWHGAFSSDAATGGAIGAFVAGMRRAVFASEAGVGSAVMAHSLAR
ARHPVSEGLVALLEPLLGTMIVCALGGLALVVAGTWNNGLEGIAITSAAFAKVSPWFPWL
LAVVVFLFAYSTLVAWGFYGLQAWGYLFGNGPRAQWVYKILYVVALPPAAAIDLGRVVGI
VDSSFFLMAIPNVIALYLCAGELRRDVKAYLAEQA