Protein Info for GFF2575 in Sphingobium sp. HT1-2

Annotation: Phosphoglucosamine mutase (EC 5.4.2.10)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02878: PGM_PMM_I
  • amino acids 3 to 135 (133 residues), 150.9 bits, E=3.6e-48
• TIGR01455: phosphoglucosamine mutase
  • amino acids 6 to 442 (437 residues), 625.4 bits, E=2.4e-192
• PF02879: PGM_PMM_II
  • amino acids 157 to 254 (98 residues), 59.4 bits, E=8.8e-20
• PF02880: PGM_PMM_III
  • amino acids 258 to 366 (109 residues), 124.9 bits, E=3.6e-40
• PF00408: PGM_PMM_IV
  • amino acids 374 to 439 (66 residues), 65.6 bits, E=7.1e-22

Best Hits

Swiss-Prot: 77% identical to GLMM_SPHAL: Phosphoglucosamine mutase (glmM) from Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256)

KEGG orthology group: K03431, phosphoglucosamine mutase [EC: 5.4.2.10] (inferred from 92% identity to sjp:SJA_C1-27460)

Predicted SEED Role

"Phosphoglucosamine mutase (EC 5.4.2.10)" in subsystem Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 5.4.2.10)

MetaCyc Pathways

• O-antigen building blocks biosynthesis (E. coli) (10/11 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• dTDP-β-L-rhamnose biosynthesis (5/5 steps found)
• superpathway of anaerobic sucrose degradation (15/19 steps found)
• glycogen biosynthesis I (from ADP-D-Glucose) (4/4 steps found)
• glycogen degradation II (5/6 steps found)
• UDP-α-D-glucose biosynthesis (2/2 steps found)
• sucrose biosynthesis I (from photosynthesis) (7/9 steps found)
• glucose and glucose-1-phosphate degradation (4/5 steps found)
• sucrose degradation II (sucrose synthase) (4/5 steps found)
• glycogen degradation I (6/8 steps found)
• sucrose degradation IV (sucrose phosphorylase) (3/4 steps found)
• GDP-α-D-glucose biosynthesis (2/3 steps found)
• trehalose degradation V (2/3 steps found)
• superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis (4/6 steps found)
• D-galactose degradation I (Leloir pathway) (3/5 steps found)
• glucosylglycerol biosynthesis (3/5 steps found)
• sucrose biosynthesis II (5/8 steps found)
• starch degradation III (2/4 steps found)
• starch degradation V (2/4 steps found)
• colanic acid building blocks biosynthesis (7/11 steps found)
• peptidoglycan recycling I (9/14 steps found)
• starch biosynthesis (6/10 steps found)
• chitin biosynthesis (5/9 steps found)
• glycogen biosynthesis III (from α-maltose 1-phosphate) (4/8 steps found)
• CDP-6-deoxy-D-gulose biosynthesis (1/5 steps found)
• CMP-legionaminate biosynthesis I (2/10 steps found)
• superpathway of dTDP-glucose-derived O-antigen building blocks biosynthesis (5/19 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (7/24 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (13/33 steps found)
• streptomycin biosynthesis (1/18 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Nucleotide sugars metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.4.2.10

Protein Sequence (446 amino acids)

>GFF2575 Phosphoglucosamine mutase (EC 5.4.2.10) (Sphingobium sp. HT1-2)
MSRQYFGTDGIRGRTNQWPMTPQLAMKVGMAAGTHFQRGSHRHRVVIGKDTRLSGYMVEN
ALVAGFTAVGMDVVQFGPIPTPAVAMLAHSMRADLGVMISASHNPYYDNGIKLFGPDGYK
LSDEDELKIEALLNQDVPLAASKDIGRARRVEDARGRYIHAVKSSFPADLRLDGLKIVVD
CANGAAYQVAPSAFWELGAEVVAVGVTPNGTNINDGCGSTSPLLCQETVVSSGADIGIAL
DGDADRLIVVDEKGQIVDGDQIMALIASNFARAGTLRGGGLVATIMSNLGLERFLTGQGI
GLERTKVGDRYVLERMREGGFNVGGEQSGHMILSDYATTGDGTVAALQVLAALVRSGKPA
SETLHQFDPVPQLLKNVRFAGGKPLEDEAVQRVIAQAEAELNGSGRLVIRPSGTEPVIRV
MAEGDREDQVKDVVERICAAVEKAAA