Protein Info for PS417_13105 in Pseudomonas simiae WCS417

Annotation: MFS transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 412 transmembrane" amino acids 44 to 66 (23 residues), see Phobius details amino acids 76 to 98 (23 residues), see Phobius details amino acids 100 to 100 (1 residues), see Phobius details amino acids 107 to 129 (23 residues), see Phobius details amino acids 142 to 161 (20 residues), see Phobius details amino acids 167 to 187 (21 residues), see Phobius details amino acids 220 to 241 (22 residues), see Phobius details amino acids 253 to 275 (23 residues), see Phobius details amino acids 287 to 304 (18 residues), see Phobius details amino acids 310 to 333 (24 residues), see Phobius details amino acids 345 to 368 (24 residues), see Phobius details amino acids 374 to 395 (22 residues), see Phobius details PF12832: MFS_1_like" amino acids 15 to 379 (365 residues), 64.8 bits, see alignment E=7.7e-22 PF07690: MFS_1" amino acids 18 to 294 (277 residues), 106.1 bits, see alignment E=1.9e-34 amino acids 250 to 401 (152 residues), 55.6 bits, see alignment E=4.4e-19

Best Hits

Swiss-Prot: 56% identical to Y2456_MYCTU: Uncharacterized MFS-type transporter Rv2456c (Rv2456c) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: None (inferred from 97% identity to pfs:PFLU2906)

Predicted SEED Role

"Major facilitator family transporter"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7TZ97 at UniProt or InterPro

Protein Sequence (412 amino acids)

>PS417_13105 MFS transporter (Pseudomonas simiae WCS417)
MAKHSDLRNALSLDSLNFFLADVRDGLGPYLAIYLLAVHKWDPASIGVVMTLAGIAALLT
QGPAGALIDRTRSKRAVVALAAIVVTGSCLLLPFVSSFSLVALTQAASAVAASVFAPAIS
AISLGITGPRAFTRRTGRNETFNHAGNAVAALLAGGLAYLFGPVVVFYLMAFMAVASVIA
ISCVSAEAIDHDVARGFDPEHHTDHEQPSGISVLLSNRPLLLFAICCALFHLANAAMLPL
VSQKLSQINLQMATPLTSACIVAAQLVMVPMAWLVGLKADIWGRKPLLMAGFIILPLRGV
LYTLSSDPYWLVAVQMLDGIGAGIFGALFPVIVKDLTQGTGRFNVSLGALSTVFGLGAAL
SSSLAGFVVQQAGYNAAFLTLAGVAALALALLWLAMPETLAKPSFARHTTVA