Protein Info for GFF2539 in Sphingobium sp. HT1-2

Annotation: hypothetical protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 612 transmembrane" amino acids 6 to 28 (23 residues), see Phobius details amino acids 181 to 205 (25 residues), see Phobius details PF05227: CHASE3" amino acids 40 to 171 (132 residues), 91 bits, see alignment E=1e-29 PF00672: HAMP" amino acids 204 to 256 (53 residues), 34.6 bits, see alignment 2.9e-12 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 438 to 603 (166 residues), 172.3 bits, see alignment E=3.7e-55 PF00990: GGDEF" amino acids 442 to 600 (159 residues), 158.7 bits, see alignment E=1.6e-50

Best Hits

Predicted SEED Role

"Putative Heme-regulated two-component response regulator" in subsystem Putative hemin transporter or cAMP signaling in bacteria

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (612 amino acids)

>GFF2539 hypothetical protein (Sphingobium sp. HT1-2)
LVGSLSHRIVVLCGILCVVMVLLAGLLLDGSAQMRSSLGWVTHSSQVLKTANRTLGHLQE
AESGQRGYVLTRNPEFGETVAAEIAAAKHEAAALVNLTADNPPQNERARQVRALVTERAA
SLEKSAAMTRAGDFAGAQASTATGRGRYLMLMVEARVGDLLAEERSLSVERMGAVERRLN
YIRWLVLLGTPLTVAIIVIMGVALIRGIRRPVEAMMTVMGKLGAGDRSARIDVEMRSSEF
ERLAGGYNEMARELEAAVADQVDSEGRLKIANQELSANAQVLRERGEVIELLGGMAHRMQ
AARTDEELASIIRVFVPRVLPDIPGALYAHNNSRNLLVPIAAWGGLEVEQAGFAPDQCWA
LRRGQSHYVTEQGSDIVCAHVGAEADHYHCEPLLAGGEVIGVLYLRGVVGAENRFRLTVL
TENIASALVNHRLQRGLREQTIRDPLTSLFNRRYMEETLALEIARATRTGSPLSLVMCDV
DHFKRFNDEFGHEAGDAVLQAVATEMRSRFRDGDVVCRFGGEEFTIIAPGTSAVVLADRV
EIVRQAISELMVNQGGRTLGSTTMSFGVATWEESMERDGSTLIKAADAALYRAKREGRNR
VVLDARAEALSA