Protein Info for GFF2534 in Xanthobacter sp. DMC5

Annotation: Oxalyl-CoA decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 586 transmembrane" amino acids 439 to 456 (18 residues), see Phobius details TIGR03254: oxalyl-CoA decarboxylase" amino acids 26 to 579 (554 residues), 1024.9 bits, see alignment E=0 PF02776: TPP_enzyme_N" amino acids 29 to 145 (117 residues), 107.4 bits, see alignment E=6.2e-35 PF00205: TPP_enzyme_M" amino acids 220 to 350 (131 residues), 124.1 bits, see alignment E=5.3e-40 PF02775: TPP_enzyme_C" amino acids 418 to 559 (142 residues), 92.7 bits, see alignment E=3.2e-30

Best Hits

Swiss-Prot: 63% identical to OXC_ECOLI: Oxalyl-CoA decarboxylase (oxc) from Escherichia coli (strain K12)

KEGG orthology group: K01577, oxalyl-CoA decarboxylase [EC: 4.1.1.8] (inferred from 93% identity to xau:Xaut_0486)

MetaCyc: 65% identical to oxalyl-CoA decarboxylase monomer (Oxalobacter formigenes)
Oxalyl-CoA decarboxylase. [EC: 4.1.1.8]

Predicted SEED Role

"Oxalyl-CoA decarboxylase (EC 4.1.1.8)" in subsystem Alkaloid biosynthesis from L-lysine (EC 4.1.1.8)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (586 amino acids)

>GFF2534 Oxalyl-CoA decarboxylase (Xanthobacter sp. DMC5)
MATAEKSKIEDNVVHIDPAAEAERELTDGFHLVIDALKLNGIETIYGVPGIPITDLGRMC
QAEGIRVISFRHEQNAGNAAAIAGFLTKKPGICLTVSAPGFLNGLTALANATTNCFPMIL
ISGSSEREIVDLQQGDYEEMDQLAIAKPLCKAAFRVLHAADIGIGVARAIRAAVSGRPGG
VYLDLPAKLFGQVMDAEAGAKSLVKVIDPAPAQIPAPAAVDRAIELLKGAERPLVILGKG
AAYAQADDEIRAFIEKSGIPFLPMSMAKGLLPDTHPQSAGAARSTALKDADVVLLVGARL
NWLLSHGKGKTWGDAPKKFIQVDIEPKEMDSNVEIAAPLVGDIGSVIAALNARLDGSWKT
PPAQWTEAIRTKKEANIAKMAPKLLKNSVPMDFHSALGALKNVIKERPDALLVNEGANTL
DLARGIIDMYEPRKRLDVGTWGVMGIGMGFAIAAAVETGKKVLAVEGDSAFGFSGMEVET
ICRYNLPVTIVIFNNNGIYRGTDTDPTGRDPGTTVFVPGSRYDKMMEAFGGVGVNVTSPD
ELYRAVSAAMDSGKPTLINAEIDPAAGSESGNIGSLNPQSVVKKKK