Protein Info for GFF2498 in Sphingobium sp. HT1-2

Annotation: Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 680 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details transmembrane" amino acids 289 to 313 (25 residues), see Phobius details amino acids 334 to 354 (21 residues), see Phobius details amino acids 373 to 394 (22 residues), see Phobius details amino acids 411 to 433 (23 residues), see Phobius details amino acids 443 to 466 (24 residues), see Phobius details amino acids 487 to 503 (17 residues), see Phobius details amino acids 509 to 529 (21 residues), see Phobius details amino acids 540 to 559 (20 residues), see Phobius details PF11412: DsbD_N" amino acids 40 to 159 (120 residues), 67.2 bits, see alignment E=1.4e-22 PF13899: Thioredoxin_7" amino acids 579 to 659 (81 residues), 52.1 bits, see alignment E=6.1e-18

Best Hits

KEGG orthology group: None (inferred from 74% identity to sch:Sphch_1381)

Predicted SEED Role

"Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8)" in subsystem Biogenesis of c-type cytochromes or Periplasmic disulfide interchange (EC 1.8.1.8)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.8.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (680 amino acids)

>GFF2498 Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8) (Sphingobium sp. HT1-2)
MRIFQVIFVTLAMLAGLSIASPAVQAQAAFGGGPAHIAAQLMAESAAPAPGKGTTIAFAM
KPEKGWHGYWENPGDAGLGMTVTWTLPKGVTIGVLRYPVPETLLISGLMNHVYEGPYAVL
ANLSVAPDVAAGTRLPIRVKAEWLACTDKICVPESGELALELVAGDGKVVPAMQARFDGW
RGHLPRPLGAQATYQIVDGKLRLSVPFPADAQAREVHLFPLSDGLARFAAAQKVSREGDR
LLVETQAGEGFKGGAAQAVLRTGDHVGFLLSAMPGEVAAIAPKGLAGTILLALGGAILGG
LLLNVMPCVFPILGLKALSLAKAGGDERAARREALAYGAGVIIACLALGSLLLGLRAAGS
AVGWAFQLQDPRIILALLLLVSAIAFNLAGLFDLPAFGGGGQLAGRDGMIGAFWTGALVA
FVATPCTGPFMGAAMGTALVLPLGAALAIFAGLGLGLALPFLLLAYLPALRNRLPRPGAW
MGRLQRILSIPMFLTALGLAWLLGQQRGVGGMTIGLGAALALVLLLWWLGMRQRTGRGGW
LQVGVGAAILLVGAAMALPARAPAVAAAGEGGVVAFDAEKLDGLRAANKPVFLYFTADWC
LTCKANEAAAIERAEVRAAFEKAGVTVMMGDWTNADPAITRFLEAQGRSGVPLYLWYAPG
KEAQTLPQLLTPSTLTGLVR