Protein Info for GFF2487 in Variovorax sp. SCN45

Annotation: Two-component system sensor histidine kinase/response regulator hybrid

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1212 transmembrane" amino acids 58 to 81 (24 residues), see Phobius details amino acids 88 to 110 (23 residues), see Phobius details amino acids 125 to 153 (29 residues), see Phobius details amino acids 165 to 184 (20 residues), see Phobius details amino acids 194 to 211 (18 residues), see Phobius details amino acids 232 to 251 (20 residues), see Phobius details amino acids 272 to 301 (30 residues), see Phobius details amino acids 326 to 346 (21 residues), see Phobius details amino acids 374 to 393 (20 residues), see Phobius details amino acids 399 to 420 (22 residues), see Phobius details amino acids 441 to 463 (23 residues), see Phobius details amino acids 470 to 490 (21 residues), see Phobius details amino acids 608 to 630 (23 residues), see Phobius details amino acids 667 to 686 (20 residues), see Phobius details PF00512: HisKA" amino acids 753 to 819 (67 residues), 55.7 bits, see alignment 6.4e-19 PF02518: HATPase_c" amino acids 867 to 978 (112 residues), 93.4 bits, see alignment E=1.9e-30 PF00072: Response_reg" amino acids 1009 to 1117 (109 residues), 48.2 bits, see alignment E=1.6e-16

Best Hits

Predicted SEED Role

"Two-component hybrid sensor and regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1212 amino acids)

>GFF2487 Two-component system sensor histidine kinase/response regulator hybrid (Variovorax sp. SCN45)
MHRNGVNPEAATTTPDDAPQRIVKVRRDYNSWVASETLEDYALRYTPQRFRKWSEWRVAN
TAFGAASFLILEAVGATLLVQYGFANAFWAILATGLIIFLAGLPISVYAARYGVDMDLLT
RGAGFGYIGSTLTSLIYASFTFIFFALEAAVMAYALELALGIPPVWGYLVCALVVIPLVT
HGVSAISRLQLWTQPLWLLMLVVPFGYVLMRDPGAFAGIVHYNGVRAGTQGFNLHLFGAA
LTVGIALITQMGEQADYLRFMPARTAATARRWWAGVLAGGPGWVVLGVLKMLGGALLAYL
AITHMVPAERAVDPNQMYLAAYEYVFPNYGWAVAATALFVVISQLKINVTNAYAGSLAWS
NFFSRVAHSHPGRVVWVVFNALIAFMLMEMNVFEALGDVLGLFANIAIAWMMAVVADLVI
NKPLGLSPPGIEFKRAHLWDINPVGVGAMALASGLSITAHLGLFGPLAQAFSALIALGTA
LVASPLLAWATGGKYYLARGSWAHGAVAFAPAPGPRAVRWAKVEHDDSGQGSYRRLTVQH
CVICEREYEGPDMAHCPAYQGAICSLCCTLDARCGDLCKPHASLSAQWSAVLRWLLPRRS
WRYLDTGLGHFLLLMLVIVPLLAVVFGVLYQQELRAFGEGALELASQADVAAALAGVQKL
SLRSGFLKAYMALLVIAGIVAWWLVLAHQSRKVAQEESNRQTHLLVREIELHRETDRALQ
AAKQAADEAREVAEHAKLAAELAKQAADQANQAKSRYISAISHELRTPLNSILGYAQLMG
EDQSVPPHRQQAVAVIKRGGEHLLSLIEGTLAIAHIEAGKLTLHARPMRFADTLRELADM
FELQAAEKGLQFRFEAAGPLPEVVRADEKRVLQILINLLGNAIKFTAAGQVTLRLAYARE
FASVEIEDTGPGMPPEDIERIFEPFARGNAVGAAGASAAPGAGLGLTIAKMLTDLMGGEM
KVRSTPGEGSLFCVRLFLPRVHDTVGGIGRPLPVQRARRGYEGPRRRLLVVDNEEADRDL
LGHVLAPLGFELRSAASGHDALDLIAAGYRPDAMFVDLAMPGIDGWETIRRARKLGLTEA
SVAIVSANAFDKGLDNDVGIAPEDFFVKPVRHTELLDWLERRLGLQWTEAAAAKPVPAAA
PRALQAPSLARLRALEEAVGLGYFRGIMNQLDDIDAAQPECMAWTEAQRALARQFQFEAM
SRALAEAAVSAP