Protein Info for GFF2472 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: TonB-dependent hemin , ferrichrome receptor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 728 signal peptide" amino acids 1 to 16 (16 residues), see Phobius details TIGR01785: TonB-dependent heme/hemoglobin receptor family protein" amino acids 31 to 728 (698 residues), 367.7 bits, see alignment E=1.3e-113 TIGR01786: TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein" amino acids 33 to 728 (696 residues), 375.6 bits, see alignment E=5.2e-116 PF07715: Plug" amino acids 44 to 165 (122 residues), 81.5 bits, see alignment E=6e-27 PF00593: TonB_dep_Rec_b-barrel" amino acids 283 to 689 (407 residues), 199.8 bits, see alignment E=1.5e-62

Best Hits

KEGG orthology group: K02014, iron complex outermembrane recepter protein (inferred from 45% identity to del:DelCs14_1542)

Predicted SEED Role

"TonB-dependent hemin , ferrichrome receptor" in subsystem Hemin transport system or Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (728 amino acids)

>GFF2472 TonB-dependent hemin , ferrichrome receptor (Hydrogenophaga sp. GW460-11-11-14-LB1)
LCLACLALLAGPALAQTAPDAVQLAQASTLREVVVSGSRSERAIEDVPASIDVITGEDLD
PARVQDIRDLVREVPNMSVRRAPQRFGGVTGSTGRDGNAGFNLRGLEGNRVLLTVDGIRV
PRELSSGVFGSASFGRDYYDLGLISRVEIVRGANSALYGSDGLAGMVAMFTTEPKDLLKP
GQTFGGRVGLKADSEDHSRGVGVTLVGAPNDTLQWLGSVQVGRSGELDNQGTNESLNSTR
TAPNPQKDKNVSLLGKVVLTPGGGQRHTLTLEHVDKSGEVEAYTARATSMGVTTQDVDGT
TDMERTRLSWDGRFKVDSAWADELRATVGYQQAESQEVSTERRSAAPTYRVRDVTYTEKL
WQGVLQAEKARSLGADWGQKLVYGVDVSVAKMDNIVTGVGAPSYESYPLKRFPPTSETNT
ALFVQSEFASERWSIIPALRYDRFDLKAKGSPLYPLQPASLSDSALSPKLGAIFRAGAEL
NLFANLAAGFKAPSALQLNNYFQNTLASYRTIPNPNLKPESSRTLELGVRDKVGPVQWEV
AAFTGRYKDFIEELVVVGGVAGNPLNPLTYQAVNRGQVRLSGFELKGKFALGPATDLRLA
YGQTKGKDTRLGAPLNTVNPARLMLGVDQRVGDWKLGAVVAHTMKKSTSDINYANLANQF
APPSYTTLDLRASWQVSKATKLSAAIHNLTDRKYWEWTNVVGVAANSPVLDAYTAPGRSL
SVALVTDF