Protein Info for GFF2468 in Sphingobium sp. HT1-2

Annotation: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00878: phosphoribosylformylglycinamidine cyclo-ligase
  • amino acids 8 to 338 (331 residues), 429.1 bits, E=5.7e-133
• PF00586: AIRS
  • amino acids 60 to 165 (106 residues), 85.7 bits, E=3.1e-28
• PF02769: AIRS_C
  • amino acids 177 to 341 (165 residues), 119.6 bits, E=1.5e-38

Best Hits

Swiss-Prot: 83% identical to PUR5_SPHAL: Phosphoribosylformylglycinamidine cyclo-ligase (purM) from Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256)

KEGG orthology group: K01933, phosphoribosylformylglycinamidine cyclo-ligase [EC: 6.3.3.1] (inferred from 91% identity to sch:Sphch_2819)

Predicted SEED Role

"Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)" in subsystem De Novo Purine Biosynthesis (EC 6.3.3.1)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (23/26 steps found)
• 5-aminoimidazole ribonucleotide biosynthesis I (5/5 steps found)
• superpathway of 5-aminoimidazole ribonucleotide biosynthesis (5/6 steps found)
• 5-aminoimidazole ribonucleotide biosynthesis II (4/5 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.3.1

Protein Sequence (364 amino acids)

>GFF2468 Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (Sphingobium sp. HT1-2)
MSDNESYSYAKAGVDIAAGNALVRAIAPLAKATRRPGADAELGGFGGFFDLKAAGYDDPL
LVAANDGVGTKLKLAIDHDRHDGVGIDLVAMCANDLIVQGAEPLFFLDYYATGKLESGVA
ERVIAGIAEGCRQAGCALIGGETAEMPGMYSDGDYDLAGFCVGAVERSKALTGNKVKAGD
VLIGLASSGVHSNGFSLVRRLAADKGWKLDRPALFDNEVLLIDALMAPTKIYVKSLLPLV
RAGMINALAHITGGGLLENIPRVLPEGTHAIVDADAWEQPRLMAFLQAQGNIEPEEMART
FNCGIGMILAVDEAHVAGVTQALEDASETVFRVGTVSEGDKGCTVKGSAETWSAKADWSA
THLG