Protein Info for GFF2464 in Variovorax sp. SCN45

Annotation: Sensory histidine kinase BaeS

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 586 transmembrane" amino acids 63 to 86 (24 residues), see Phobius details amino acids 280 to 301 (22 residues), see Phobius details PF00672: HAMP" amino acids 299 to 350 (52 residues), 61 bits, see alignment 1.7e-20 PF00512: HisKA" amino acids 356 to 411 (56 residues), 43.7 bits, see alignment 3.4e-15 PF02518: HATPase_c" amino acids 469 to 583 (115 residues), 85.4 bits, see alignment E=5.7e-28

Best Hits

KEGG orthology group: K07642, two-component system, OmpR family, sensor histidine kinase BaeS [EC: 2.7.13.3] (inferred from 81% identity to vpe:Varpa_4873)

Predicted SEED Role

"Sensory histidine kinase BaeS"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (586 amino acids)

>GFF2464 Sensory histidine kinase BaeS (Variovorax sp. SCN45)
MEGPGRDFSQFPPHSADTIGVLPPSFVHRRPPFSPDSPVAMHAAECGHARALPMPQLTLS
RKIFLALAALLLVLLISFAGLSIIALQRGLGSYVAEIEIRRMDWLAQLVLKNYVAHGDWK
NLRDNDDAWQRLQMGRFASLLDSTAANGDERRLPPWYEYRTMRPEPPPDGAPTGAPAGAP
NGDPPPMPPSPQLDLLPRRMLGAPPPWVFPDPRGMHDSIYQRLAVLDASGARVVGADIDM
ANAARMPIRHNKSVIGYLALAPLQGLESEADRAFIARQSGVIVLTGLCGLGFALVLSWLL
ARRWFRPIDELTQAAQDVAQGRLSTRVAVQGSDELALLGKTFNDMAQRLDTVEASRRAWL
ADAAHELRTPLAAMRAEIEALQDGVRTFDERTALRLHRQVIRLGQLVDDLRSSMREPQSD
LLTTTVFPLSLLKEALDHTRDRFAKRGIVVDRHAVDHVTASAQPVIDGNAHRLHQVFMNL
LENTLAYTDEGGKLRLDVIVEGAWTGNCLTLLFDDSAPGVPDEELPRLFDRLFRGETSRS
REHGGSGLGLSICRATIEAHGGTIEASASPLGGLRVTITLPLATSS