Protein Info for GFF2450 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Transcriptional activator of cad operon

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 514 transmembrane" amino acids 161 to 184 (24 residues), see Phobius details PF00486: Trans_reg_C" amino acids 24 to 100 (77 residues), 62.9 bits, see alignment E=2.5e-21 PF18500: CadC_C1" amino acids 194 to 326 (133 residues), 254.9 bits, see alignment E=1.7e-80

Best Hits

Swiss-Prot: 58% identical to CADC_ECOLI: Transcriptional activator CadC (cadC) from Escherichia coli (strain K12)

KEGG orthology group: K03765, transcriptional activator of cad operon (inferred from 100% identity to sew:SeSA_A2799)

Predicted SEED Role

"Transcriptional activator of cad operon" in subsystem Lysine degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (514 amino acids)

>GFF2450 Transcriptional activator of cad operon (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MQQPVVRIGEWLVTPSVNQISRQGRQITLEPRLIDLLMYFAHHPDEVLSRDNIIDHVWMR
TIVTNHVVTQSISELRKSLRDGGDSNAEYIVTVPKRGYKLTAPVIWCEENSDEIDNSSTS
PPPPIAATNAEPTEGVTAATPVPPASLQTPTKKAKKPRIAAFWTWVMFLLSLATLVVFIV
MSVVDHNAAVTKTRLLLNPRDIDVRFEGGNSCNNWVSQESYAIGLGGLITDLLNTYSTFM
VHDKTNYRVNEPSSSGKTLTIQFVNQRHYRAQQCFMSVVLIDNADGSTMLDKRYFVTNTN
QLSIQDDLFNSLSFVLTQPWPNRMREQLALFRTPQNTALMRFYEARQLILSGDAQALGKA
SDILNGIIKETPDFNYAYEYKVLVDVLRQSQQPFDKEQVAALNEEFKKIDQIPGVEKTSV
YYKIKTVDLLGKGDIDAAYEEINKSIELEMSWFNYVLLGKVYEMKGENRLAADAYLTAFN
LRPGENTLYWIENGVFQTSVQKIVPYLNSFLAED