Protein Info for GFF245 in Sphingobium sp. HT1-2

Annotation: Cardiolipin synthase, bacterial type ClsA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 471 transmembrane" amino acids 12 to 30 (19 residues), see Phobius details amino acids 39 to 58 (20 residues), see Phobius details amino acids 189 to 207 (19 residues), see Phobius details PF13396: PLDc_N" amino acids 22 to 59 (38 residues), 24 bits, see alignment 4.7e-09 TIGR04265: cardiolipin synthase" amino acids 27 to 471 (445 residues), 293 bits, see alignment E=2.4e-91 PF13091: PLDc_2" amino acids 130 to 270 (141 residues), 51.8 bits, see alignment E=1.2e-17 amino acids 314 to 432 (119 residues), 94.8 bits, see alignment E=5.7e-31

Best Hits

KEGG orthology group: K06131, cardiolipin synthase [EC: 2.7.8.-] (inferred from 50% identity to zmn:Za10_0915)

Predicted SEED Role

"Cardiolipin synthetase (EC 2.7.8.-)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 2.7.8.-)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.8.-

Use Curated BLAST to search for 2.7.8.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (471 amino acids)

>GFF245 Cardiolipin synthase, bacterial type ClsA (Sphingobium sp. HT1-2)
MVNLPDSDFGLFYYILEWAIRIGALIAVPFRRTPAATRAWLLLIFFLPVPGLILFWIIGS
PRFPEWRRARFGELDPWFGGIAARLLPHAPSPDPDRAPIVDLAAKLGKMPATGGNRVDLI
FDYIVAIDRLVADINAARHSVRILVYIFADDAVGRRVADALGAAVKRGVTVQVMYDPVGS
RPWRKGMEAMLTAAGVELCAALPFRWIRGRTRRDMRNHRKLFVIDGVIGHVGSQNIVTRD
FKPGIVNQELVARVAGPVVAELEALVRADWYMETHRLPEGPVVIPEPAGDAVTQLLPSGS
NYPLEGFKTLLVWQLHQARSHVMLVTPYFIPDDDLVDAMRTAVVRGVKVDLIVSKPVDQW
LVHAAQASYYAELMAAGIGIHAHRPEFVHAKTVSIDGRVAVVGSSNVDMRSFELNEEASL
LIYDAETVAAVELVQRRFMARAETLDRETWRARPLYRKVAENVARMVGSLL