Protein Info for GFF244 in Variovorax sp. SCN45

Annotation: Cys regulon transcriptional activator CysB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 313 PF00126: HTH_1" amino acids 11 to 64 (54 residues), 52.3 bits, see alignment 4.4e-18 PF03466: LysR_substrate" amino acids 89 to 295 (207 residues), 152.8 bits, see alignment E=8.9e-49

Best Hits

Swiss-Prot: 59% identical to CYSB_BURCJ: HTH-type transcriptional regulator CysB (cysB) from Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)

KEGG orthology group: K13634, LysR family transcriptional regulator, cys regulon transcriptional activator (inferred from 100% identity to vpe:Varpa_2825)

Predicted SEED Role

"Alkanesulfonate utilization operon LysR-family regulator CbI" in subsystem DNA-binding regulatory proteins, strays

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

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Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (313 amino acids)

>GFF244 Cys regulon transcriptional activator CysB (Variovorax sp. SCN45)
MNLHQFKFVQEAVRRNLNLTEAAKALHTSQPGVSKAIIELEEELGVEIFARHGKRLKRVT
EPGQHVIASIELIMREVGNLKRIGEQFSAQDSGTLSIATTHTQARYVLPVPVANLREAYP
KVNVSLHQGSPDQVARMVIDEIAEIGIATESLDGYAELVTLPCYEWQHVLVLPKDHPLAA
KERISLEDLASEPIITYHPSFTGRTRIDHAFAQKKLTPRIALEAIDSDVIKTYVRLGLGV
GIVAEMAVRDESNADLVVRPMGHVFGQNIARVAFKRSAYLRNFVFKFAELLSDRLDRNLI
AKALSGHQQDYEL