Protein Info for GFF244 in Sphingobium sp. HT1-2

Annotation: Prolyl endopeptidase (EC 3.4.21.26)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 708 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details PF02897: Peptidase_S9_N" amino acids 31 to 416 (386 residues), 98 bits, see alignment E=5.6e-32 PF00326: Peptidase_S9" amino acids 502 to 703 (202 residues), 147.4 bits, see alignment E=4.4e-47

Best Hits

Predicted SEED Role

"Prolyl endopeptidase (EC 3.4.21.26)" (EC 3.4.21.26)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.26

Use Curated BLAST to search for 3.4.21.26

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (708 amino acids)

>GFF244 Prolyl endopeptidase (EC 3.4.21.26) (Sphingobium sp. HT1-2)
MRHKLTLRSALMAIAIASAPALIAAAPATGDDPYLWLEDIEGAKAIAQVEQWNGETEKLL
RASPRFEADRARARAILDDESQIAVPDKVMGDRVTNLWRDAKNPRGLWRSSDLASYLAGK
PNWTTIIDVDALGKAEGKSWVWHGADCLAPDYSRCLISLSAGGTDADVVREYDLATGKFV
EGGFTLPEAKSDVAWADKDTLLVGTDYGAGSLTASGYPRIVKRWKRGTPLSAATLVKEGV
DSDISVRPRVEQDGTKSWVFIDRALTFYTNDLYVEGANGQLIRTPVPDTADFRGLIGGQM
IVLLNKPLGDIPTGSLVSWPIADVAAGKAGAPQVVLKPTATTVVEEVRTTDHILWVKQLD
NVSGALLAMTRDAATGRWTSRSVPLADKATVHLVGTDDKGDRVFASVEGMLTPPSLMVAG
AQGAAQTIQQLPARFDASQFVVEQRFATSKDGTKVPYFLARKKGVTGPVPAFIHAYGGFR
AAQTPTYLTTEPYRAGPLGLFWVEDGNAYVLANIRGGGEYGPAWHQDALREKRQNAFDDL
AAVAEDLVKTGVSTKGDIGISGRSNGGVLVGAAMTQRPDLYGAVIAGSPLEDMKRYSHLS
AGASWVAEYGDPDVPSDWAFMAKWSPYQNVKTGVQYPPAFFYLSTKDDRVHPGHARKMAA
KLKATGSTVYYHEYREGGHSVGADHAEDAVRAALLHAFLTRELVEKKK