Protein Info for GFF2435 in Variovorax sp. SCN45

Annotation: FIG138928: iron-regulated membrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 558 transmembrane" amino acids 21 to 41 (21 residues), see Phobius details amino acids 167 to 188 (22 residues), see Phobius details amino acids 210 to 234 (25 residues), see Phobius details amino acids 377 to 399 (23 residues), see Phobius details amino acids 419 to 441 (23 residues), see Phobius details amino acids 455 to 473 (19 residues), see Phobius details amino acids 484 to 503 (20 residues), see Phobius details amino acids 517 to 535 (19 residues), see Phobius details PF03929: PepSY_TM" amino acids 15 to 400 (386 residues), 214.7 bits, see alignment E=1.4e-67

Best Hits

KEGG orthology group: None (inferred from 68% identity to del:DelCs14_3489)

Predicted SEED Role

"FIG138928: iron-regulated membrane protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (558 amino acids)

>GFF2435 FIG138928: iron-regulated membrane protein (Variovorax sp. SCN45)
MSKQARQGGFRQAQAWLHTWCGLWFSWLLFAVFLTGTLAVFDEPITHWMTPEHRAEEAAE
AAEAAAPKTTDAATAGRAQRLAWGVAYMAEHHPAARMWELWPSDAKGGGGLTVYWLDADN
RYVSASLDPATGRPLAAAAGAGAHAVRATLGGHHFVDFHYELHAGTVGLWIVGIAAMAML
VALLSGVITHKRIFKDFFTFRPKKGQRSWLDAHNAVAVLTLPFQFMIAYTGLVISGTSFM
PAGKVLHYGTGSTAQAQFVSELSDGVKPRRAGRAMAVPDLEAFAARGQQLTGQPVRAVVI
DHPGDAGARIGIYGWNGDDEALRRINANTGMAQFSAATGELLRVRLPGASDGGAALLAQS
TMSGLHMATFGGWGMKWLYFLCGLAGTAMMGTGAILFIVKRRQKHLGEFGGATARVYRLV
EALNVAAIAGLALACIGFLWANRLIPVDIAQRADWELRAFFAVWALALAHAFVRPPARAW
RDQLGVLAALCLLLPALDLLTTGDHLPAQLTRGDWESTGVALTAMAFGLAALGALRHLRG
IRRNSSAAALPASSESAA