Protein Info for PS417_12240 in Pseudomonas simiae WCS417

Annotation: lysine decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03709: OKR_DC_1_N
  • amino acids 22 to 143 (122 residues), 74.5 bits, E=1.2e-24
• PF01276: OKR_DC_1
  • amino acids 149 to 581 (433 residues), 519 bits, E=1.3e-159
• PF03711: OKR_DC_1_C
  • amino acids 607 to 737 (131 residues), 166 bits, E=8.1e-53

Best Hits

KEGG orthology group: K01584, arginine decarboxylase [EC: 4.1.1.19] (inferred from 99% identity to pfs:PFLU2647)

Predicted SEED Role

No annotation

MetaCyc Pathways

• superpathway of arginine and polyamine biosynthesis (15/17 steps found)
• superpathway of putrescine biosynthesis (4/4 steps found)
• L-arginine degradation IV (arginine decarboxylase/agmatine deiminase pathway) (3/3 steps found)
• putrescine biosynthesis II (3/3 steps found)
• superpathway of L-arginine and L-ornithine degradation (10/13 steps found)
• L-arginine degradation III (arginine decarboxylase/agmatinase pathway) (2/2 steps found)
• putrescine biosynthesis I (2/2 steps found)
• arginine dependent acid resistance (1/1 steps found)
• superpathway of polyamine biosynthesis I (6/8 steps found)
• superpathway of polyamine biosynthesis II (6/8 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (8/11 steps found)
• spermidine biosynthesis III (1/4 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

Compare fitness of predicted isozymes for: 4.1.1.19

Use Curated BLAST to search for 4.1.1.19

Sequence Analysis Tools

See A0A1N7TYZ1 at UniProt or InterPro

Protein Sequence (751 amino acids)

>PS417_12240 lysine decarboxylase (Pseudomonas simiae WCS417)
MYKDLKFPVLIVHRDIKADTVAGDRVRGIARELEQEGFSIFSAVDYAEGRLVASTHHGLA
CMLIAAEGAGENTHLLQNMVELIRLARLRAPNLPIFALGEQVTLENAPADAMSELNQLRG
ILYLFEDTVPFLARQVARAARTYLDGLLPPFFKALVQHTADSNYSWHTPGHGGGVAYRKS
PVGQAFHQFFGENTLRSDLSVSVPELGSLLDHTGPLAEAEARAARNFGADHTFFVINGTS
TANKIVWHSMVGRDDLVLVDRNCHKSVLHSIIMTGAIPLYLCPERNELGIIGPIPLSEFS
PESIRAKIDASPLTRGRPPKVKLAVVTNSTYDGLCYNAELIKQQLGNSVEVLHFDEAWYA
YAAFHEFFAGRYGMGTSRTPDSPLVFTTHSTHKLLAAFSQASMIHVQDGGARQLDRDRFN
EAFMMHISTSPQYSIIASLDVASAMMEGPAGRSLLQEMFDEALSFRRALANLRQHIAEED
WWFSIWQPPSVAGIDRVVTADWLLHPQDDWHGFGDVAEDYVLLDPIKVTLVMPGLTAGGA
LSDCGIPAAVVSKFLWERGLVVEKTGLYSFLVLFSMGITKGKWSTLLTELLEFKRSYDAN
VSLASCLPSVFAQGPTRYQGLGLRDLCDQLHSCYRSNATAKHLKRMYTVLPEIAMKPADA
YDQLVRGEVEAVSIDALPGRIAAVMLVPYPPGIPLIMPGERFTESTRSIIDYLAFARTFD
SSFPGFVADVHGLQHEDDGSGRCYTVDCIKG