Protein Info for GFF2377 in Sphingobium sp. HT1-2

Annotation: Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 281 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details PF00106: adh_short" amino acids 7 to 191 (185 residues), 161.4 bits, see alignment E=2.8e-51 PF08659: KR" amino acids 8 to 164 (157 residues), 36.9 bits, see alignment E=5.3e-13 PF13561: adh_short_C2" amino acids 13 to 196 (184 residues), 125.4 bits, see alignment E=4.1e-40

Best Hits

KEGG orthology group: None (inferred from 72% identity to bpy:Bphyt_2007)

Predicted SEED Role

"Short-chain dehydrogenase/reductase SDR"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (281 amino acids)

>GFF2377 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) (Sphingobium sp. HT1-2)
MSALIPKTFLITGVSSGLGRAFAEGALDAGHAVVGTVRNPKDADAFAALAPGRAHPLQLD
VTHLDAIPAAVADAERRAGPIDILVNNAGYGHEGVLEESSIDDLQRQFAANVFGPVAMMK
AVLPGMRERRRGHIVNITSMGGFITMPGISFYCGSKFALEGISEALGKEVAPFGIHVTAL
APGQFRTDWAGRSMDRTPRSIADYDAVMDPIRAARQAKSGQQPGDPARAAQALLVLVDAP
APPTRLFLGDDALGLVEGKMAAMEAEIAQWRALSRSTSFAA