Protein Info for GFF2313 in Variovorax sp. SCN45

Annotation: Two-component system sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 593 transmembrane" amino acids 24 to 48 (25 residues), see Phobius details amino acids 54 to 71 (18 residues), see Phobius details amino acids 91 to 109 (19 residues), see Phobius details amino acids 115 to 133 (19 residues), see Phobius details amino acids 142 to 160 (19 residues), see Phobius details amino acids 166 to 186 (21 residues), see Phobius details PF00512: HisKA" amino acids 222 to 286 (65 residues), 40.5 bits, see alignment E=3.6e-14 PF02518: HATPase_c" amino acids 331 to 439 (109 residues), 95.6 bits, see alignment E=3.8e-31 PF00072: Response_reg" amino acids 468 to 585 (118 residues), 38.3 bits, see alignment E=2e-13

Best Hits

KEGG orthology group: None (inferred from 73% identity to vap:Vapar_4376)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (593 amino acids)

>GFF2313 Two-component system sensor histidine kinase (Variovorax sp. SCN45)
VAPSEPSADYMLGQRVLRENIASVYSTYIASTLTHMAFVLVFGAIIYSQLKDPSLLFWLA
TLLIADIYVLFTPRWTPARPARESAYWARKISRMVTLVSMITAVVPWLIVPHDNLPMTSL
LMAVIVGSCARAAQSLWPLKPALFGYTMPMSLGMITALAWQGDGLHLFLAAAGAAYLLLT
LHAGVGQHKLLTESLMLRFENEALAARLGEQIAATERASEEKTRFLGTASHDLRQPLHAI
ALFGAALENELRDRPERRNAERLMRAVNALGASLDTMLDVSRLDAGVVTPAPQPVQLDAL
FLPLNHTFAARAEHKQLQLRVLASGLWVHSDPQLLHRMLSNLMDNALKYTTRGGVTVTAR
DRGEAVWIEVRDSGIGIAPEQSSRIFEEFYQVNNPGRDRSRGLGIGLSIVQRLSRLLGHP
VQMHSRPGRGTFFRVVVPAVKAPARVAAAGALSTRRSDKPEAVLPGRVLLLDDEQEIREA
MVGLLRSHAVDAHAVDSEEAAAEALQQAAAEGRPFDLLLCDYRLADGADGLDAGLRLSQG
AAQGRAAMPLLLVTGETSPDRLQRVRESRVPVLFKPVAAESLLRAMAEVVTAR