Protein Info for GFF2311 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Dihydroorotase (EC 3.5.2.3)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01979: Amidohydro_1
  • amino acids 51 to 439 (389 residues), 86.5 bits, E=2.1e-28
• PF07969: Amidohydro_3
  • amino acids 354 to 440 (87 residues), 32.7 bits, E=6e-12

Best Hits

KEGG orthology group: K01465, dihydroorotase [EC: 3.5.2.3] (inferred from 83% identity to axy:AXYL_00407)

Predicted SEED Role

"Dihydroorotase (EC 3.5.2.3)" in subsystem De Novo Pyrimidine Synthesis (EC 3.5.2.3)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (44/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (18/18 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (9/9 steps found)
• UMP biosynthesis I (6/6 steps found)
• UMP biosynthesis II (6/6 steps found)
• UMP biosynthesis III (5/6 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.5.2.3

Use Curated BLAST to search for 3.5.2.3

Protein Sequence (466 amino acids)

>GFF2311 Dihydroorotase (EC 3.5.2.3) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MDTLIRHGLIVTPQGRRVASIGIQGGRIAGIYDVGSEPEAREVIEADGLAVVPGAIDMHS
HHRQGSLPGFEYKDTIHTSTLQCAAGGVTTSVAMPNVQPPPNSLELLERQYDIYRSDAVV
DWNFNPAPTISEEMPGMADTGIAAFKIFMVVDTGRDYPHMPGIGVHDHGKILEIMQRCAE
LNVPLMVHPHDQALMDVIEQKFWDRGERDALAYAKAYAAHDGVIWETAIATLLRLQRASG
CHLHILHTQTAGSVELIRQAKAAGQKVTCEINPWALFLGCEWSAIQRLGSYALSYWVPEK
NVPGLWEGLRDGTIDIVATDHAPHTREEKEIGWTDGWKAHTGTPSTQFYYSMFMTAALEG
KISLERVVEACSAKPAELFKLANKGALKVGADADLVLVDLNREYEVRDEDVLSMIGWSPY
AGRKLKAKPVRTIVRGTTVYLNDQVIGQKGFGRQAKAVREAAAALA