Protein Info for GFF2306 in Xanthobacter sp. DMC5

Annotation: hypothetical protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 619 TIGR02397: DNA polymerase III, subunit gamma and tau" amino acids 39 to 400 (362 residues), 403.8 bits, see alignment E=3.6e-125 PF13177: DNA_pol3_delta2" amino acids 56 to 220 (165 residues), 115.6 bits, see alignment E=8.9e-37 PF13401: AAA_22" amino acids 75 to 199 (125 residues), 27.5 bits, see alignment E=1.4e-09 PF00004: AAA" amino acids 78 to 214 (137 residues), 43.1 bits, see alignment E=2.3e-14 PF22608: DNAX_ATPase_lid" amino acids 226 to 272 (47 residues), 69.9 bits, see alignment 4.9e-23 PF12169: DNA_pol3_gamma3" amino acids 274 to 416 (143 residues), 189.8 bits, see alignment E=8.6e-60 PF12362: DUF3646" amino acids 476 to 588 (113 residues), 136 bits, see alignment E=2.8e-43

Best Hits

KEGG orthology group: K02343, DNA polymerase III subunit gamma/tau [EC: 2.7.7.7] (inferred from 85% identity to xau:Xaut_2168)

Predicted SEED Role

"DNA polymerase III subunits gamma and tau (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (619 amino acids)

>GFF2306 hypothetical protein (Xanthobacter sp. DMC5)
MSDEQHTDDQQDGPGFDLGLPEAAPAVTAAPVAASPGAYRVLARKYRPQNFADLIGQEAM
VRTLRNAFSSGRIAQAYILTGVRGVGKTTTARILARALNYEPADGAAGGPSLDLAVMGKH
CRDIIESRHVDVMEMDAASNTSINDIREIIESARYRPVMARYKVYIIDEVHMLSTAAFNG
LLKTLEEPPEHVKFIFATTEIRKVPVTVLSRCQRFDLRRVEAGTLAAHLSGICAREGVTI
EPEALSIVARAAEGSVRDSLSLLDQAIAHGGGTVSADEVRRLLGLADKGRVIDLFEALMK
GEIARALAEFRDQYDSGADPAVILTDLADFTHLVTRLKIVPDAAEDAALVEAERVRGSEM
AQGLSMRVLARAWQMLSKGIGEVQQAPKPAQAAEMVLVRLAYAADLPTPDDALRRLKDQP
APSASPSAPSLPSGGGGGGGPRLSLAPRPAEARPQPRADIRVDARAAMPAEGPRLGSLAD
VAALAAARRDLALKHGIETQLRPVHVEDGRIEVALVPGAPGSLIQDLSRKLNEWTGRRWM
VSVSSQSGGPTLAEENAAVKAEREEGIKAHPLVAAVLARFPGAEVVDVRTREEPPADEGL
APSEEDYLAGPGADDEIEF