Protein Info for GFF2298 in Variovorax sp. SCN45
Annotation: Cytochrome c oxidase polypeptide I (EC 1.9.3.1)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 58% identical to COX1_RICCN: Probable cytochrome c oxidase subunit 1 (ctaD) from Rickettsia conorii (strain ATCC VR-613 / Malish 7)
KEGG orthology group: K02274, cytochrome c oxidase subunit I [EC: 1.9.3.1] (inferred from 98% identity to vpe:Varpa_5053)MetaCyc: 68% identical to cytochrome c oxidase subunit 1 (Pseudomonas putida KT2440)
Predicted SEED Role
"Cytochrome c oxidase polypeptide I (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)
MetaCyc Pathways
- aerobic respiration I (cytochrome c) (3/4 steps found)
- arsenite to oxygen electron transfer (1/2 steps found)
- aerobic respiration II (cytochrome c) (yeast) (2/4 steps found)
- arsenite to oxygen electron transfer (via azurin) (1/3 steps found)
- Fe(II) oxidation (2/6 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.9.3.1
Use Curated BLAST to search for 1.9.3.1
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (546 amino acids)
>GFF2298 Cytochrome c oxidase polypeptide I (EC 1.9.3.1) (Variovorax sp. SCN45) MSAVLDPHGHAVPGGHAHDEHHDHHAPTGWRRWVFATNHKDIGTLYLLFSFTMLMVGGVL ALLIRAELFQPGLQLVNPELFNQFTTMHGLIMVFGAIMPAFVGFANWMIPLQVGASDMAF ARMNNFSFWLLIPAALMLVGSFFMPGGAPAAGWTLYAPLTLQMGPSMDAGIFAMHIMGAS SIMGSINIIVTILNMRAPGMTLMKMPMFCWTWLITAYLLIAVMPVLAGAITMTLTDRHFG TSFFNPAGGGDPVMYQHIFWFFGHPEVYIMILPAFGIISQVVPAFARKKLFGYASMVYAT SSIAILSFIVWAHHMFTTGMPLTGQLFFMYATMLIAVPTAVKIFNWIATMWQGSMTFETP MLFAVGFIFVFTMGGFTGLILAVAPIDTQLQDTYYVVAHFHYVLVAGSLFAMFSGFYYWV PKWTGVMYNETRGKVHFWWSLISFNVTFFPMHFLGLAGMPRRYADYPMQFADFNAVASVG AFFFGFAQVYFFLFVVFPTMRGKGEKAAQKPWEGAEGLEWEVPSPAPFHTFENPPKLDAT ATKVIG