Protein Info for GFF2288 in Variovorax sp. SCN45

Annotation: Glutathione-regulated potassium-efflux system protein KefC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 618 transmembrane" amino acids 6 to 25 (20 residues), see Phobius details amino acids 30 to 51 (22 residues), see Phobius details amino acids 57 to 76 (20 residues), see Phobius details amino acids 88 to 112 (25 residues), see Phobius details amino acids 117 to 137 (21 residues), see Phobius details amino acids 149 to 172 (24 residues), see Phobius details amino acids 190 to 208 (19 residues), see Phobius details amino acids 220 to 241 (22 residues), see Phobius details amino acids 243 to 260 (18 residues), see Phobius details amino acids 275 to 294 (20 residues), see Phobius details amino acids 300 to 320 (21 residues), see Phobius details amino acids 332 to 351 (20 residues), see Phobius details amino acids 363 to 382 (20 residues), see Phobius details TIGR00932: transporter, monovalent cation:proton antiporter-2 (CPA2) family" amino acids 16 to 290 (275 residues), 276 bits, see alignment E=1.9e-86 PF00999: Na_H_Exchanger" amino acids 18 to 378 (361 residues), 202.1 bits, see alignment E=1.3e-63 PF02254: TrkA_N" amino acids 409 to 521 (113 residues), 90.7 bits, see alignment E=8.6e-30

Best Hits

KEGG orthology group: K11745, glutathione-regulated potassium-efflux system ancillary protein KefC (inferred from 95% identity to vpe:Varpa_5063)

Predicted SEED Role

"Glutathione-regulated potassium-efflux system protein KefC" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (618 amino acids)

>GFF2288 Glutathione-regulated potassium-efflux system protein KefC (Variovorax sp. SCN45)
MEHAPAWLTNSLIYLSAAVLVVPLSKALGLGSIIGYLVAGIAIGPWGLGLVSSVQDVLHF
AEFGVVLMLFLVGLELEPKRLWNLRRPIFGWGTAQVLSCAAVLFAAGCVVGAEWRVALVA
SLGLALSSTAIALQVFGERNLLKTPSGQAGFSILLFQDVAAIPILALLPLLAGATAAEQS
ISGLDRALEAAKIIGVIGGIILGGRLLLRPVLRWIARSDTPEIFTAAALLLVVAIAALMQ
LVGLSMALGAFLAGVLLAESEYRRELETDIEPFKGLLLGLFFIAVGMSINFGVLIASPWV
MAALVVGFMVVKLAVIYALAKAMGIAYQERPVFTLLLAQGGEFAFVVFQAAGPDVLPPEI
TSLLIGAVALSMLLSPLLLVLLDKFVLPRYSRNHGPQLEEISEQQDAKVLICGFGRYGQI
VGRMLMSQGLRVTVLDHDADTVEGLRQFGFRVFYGDATRLDLLRTAGAGTAKAIVVAVDD
IEQSLEIVDLVKENFPQARIIARARNVTHLFQLRDRGVTDVEREVFESSLRSARATLEAL
GWPAHEARESTMRFRRRNIKLSDEIYPHYKDRAKLIAANKAGRQQFEEQMAREREERQRR
SGRDWDRLEEEEQAEQAP