Protein Info for GFF2264 in Xanthobacter sp. DMC5

Annotation: multidrug efflux RND transporter permease subunit OqxB12

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1069 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 342 to 362 (21 residues), see Phobius details amino acids 369 to 389 (21 residues), see Phobius details amino acids 395 to 419 (25 residues), see Phobius details amino acids 440 to 462 (23 residues), see Phobius details amino acids 472 to 499 (28 residues), see Phobius details amino acids 547 to 567 (21 residues), see Phobius details amino acids 876 to 898 (23 residues), see Phobius details amino acids 905 to 927 (23 residues), see Phobius details amino acids 933 to 956 (24 residues), see Phobius details amino acids 982 to 1002 (21 residues), see Phobius details amino acids 1012 to 1035 (24 residues), see Phobius details TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 3 to 1042 (1040 residues), 1185.9 bits, see alignment E=0 PF00873: ACR_tran" amino acids 4 to 1036 (1033 residues), 1195.2 bits, see alignment E=0 PF02355: SecD_SecF_C" amino acids 344 to 497 (154 residues), 21.6 bits, see alignment E=1.9e-08 PF03176: MMPL" amino acids 346 to 498 (153 residues), 36.9 bits, see alignment E=3.1e-13 amino acids 846 to 1034 (189 residues), 21.6 bits, see alignment E=1.5e-08

Best Hits

KEGG orthology group: None (inferred from 89% identity to azc:AZC_2667)

Predicted SEED Role

"RND multidrug efflux transporter; Acriflavin resistance protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1069 amino acids)

>GFF2264 multidrug efflux RND transporter permease subunit OqxB12 (Xanthobacter sp. DMC5)
MNLSRFFIDRPIFAGVLSVLIFLAGLIAMRAMPISEYPEVVPPQVVVRATYPGANPKVIA
ETVSTPLEESINGVEGMLYMSSQATTDGIMTLTVTFKLGTDPDKAQQLVQNRISQAEPRL
PEEVRRLGVTTVKSSPDLTMVVHLISPNNRYDTTYLRNYAVLNVKDRLARIDGVGQVQLF
GAGDYSMRIWLDPQKVAEHGLSAADVVREIRAQNVQAAAGVVGASPGAPGLDLQLSINAQ
GRLANEEEFANIVVKSGTNGEIVLLKDVARIELGASEYALRSLLNNTQAVAVPIFQAPGS
NAIRIADDVRLVMDEIKANMPEGVDYSIVYDTTQFVRASIDAVVHTLLEAVALVVLVVIV
FLQTWRASIIPLLAVPVSIVGTFAVMYVFGFSINALTLFGLVLAIGIVVDDAIVVVENVE
RNIEGGLSPREATYKAMREVSGPIIAIALVLIAVFVPLAFITGLTGQFYKQFALTIAIST
VISAVNSLTLSPALSALLLKGHDAPKDWLTRTMDRLFGWFFRGFNKAFVRGSGAYGGIVR
RVIGQKVLMLGLYIVLVALTGVLFKAVPPGFVPGQDKQYLVGFAQLPDGATLDRTEEVIR
KMSDIALKEPGVKSAIAFPGLSINGFTNSSNSGIVFVGLDEFEARRDPSLNGNAIAMKLN
GKFAGIPDAMIAMFPPPPVQGLGTIGGFKFQIEDRAGLGYAALDEATKAFLGAARQAPEL
AGLFSSYQVNVPQLFADIDRVKARQLNVAVTDVFETMQIYLGSSYVNDFNKFGRTYTVRV
QADAPFRARAEDVGTLKVRSQTGEMIPLSALLKVRSSAGPERAMRYNGFLSADVNGGAAP
GFSSGEAQQAVERIAKETLPKGFSFEWTELTYQDILAGNSAVFVFPLAIFLVFLVLAAQY
ESLMLPLAIIMIVPTGLFAAMTGVWLAGGDNNVFTQIGLVVLVGLSAKNAILIVEFAREL
EFEGRTPVQAAIEASRLRLRPILMTSLAFIMGVVPLVTSIGAGAEMRQAMGTAVFAGMIG
VTVFGIFLTPVFYVMLRGLAGNRPLTQHGHAPAGSTPATHAPHALQPGE