Protein Info for GFF2251 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Transcriptional regulator, TetR family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 215 transmembrane" amino acids 164 to 178 (15 residues), see Phobius details PF00440: TetR_N" amino acids 23 to 67 (45 residues), 58.7 bits, see alignment 5.8e-20 PF17938: TetR_C_29" amino acids 91 to 207 (117 residues), 133.5 bits, see alignment E=6.1e-43 PF14514: TetR_C_9" amino acids 136 to 215 (80 residues), 38 bits, see alignment E=2.7e-13

Best Hits

Swiss-Prot: 35% identical to NICS_PSEPK: HTH-type transcriptional repressor NicS (nicS) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

KEGG orthology group: K09017, TetR/AcrR family transcriptional regulator (inferred from 53% identity to bja:bll4209)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (215 amino acids)

>GFF2251 Transcriptional regulator, TetR family (Hydrogenophaga sp. GW460-11-11-14-LB1)
MPPRRASVSSPSDADSSAARSAILAAARAEFSAKGLTGARVNEIAARAGVNKQLIYYYFG
SKEDLYRTALEVVYTEIRTQERSLKLGDMQPEEAMATLIGFSFDYLAEHPDFIGLLNHEN
AQGAQHVRDSSAIRDTNSPLIELIAKTLARGIRARVFRRGIDPVEFYISVAGMSYFFFSN
RLTLASIFGRDLSSTEAVAAYRAHVVAFAMAGLRA