Protein Info for PS417_11460 in Pseudomonas simiae WCS417

Annotation: divalent metal cation transporter MntH

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 440 transmembrane" amino acids 30 to 49 (20 residues), see Phobius details amino acids 68 to 91 (24 residues), see Phobius details amino acids 114 to 136 (23 residues), see Phobius details amino acids 142 to 161 (20 residues), see Phobius details amino acids 172 to 195 (24 residues), see Phobius details amino acids 215 to 233 (19 residues), see Phobius details amino acids 263 to 283 (21 residues), see Phobius details amino acids 304 to 321 (18 residues), see Phobius details amino acids 352 to 370 (19 residues), see Phobius details amino acids 376 to 397 (22 residues), see Phobius details amino acids 417 to 439 (23 residues), see Phobius details TIGR01197: metal ion transporter, metal ion (Mn2+/Fe2+) transporter (Nramp) family" amino acids 35 to 406 (372 residues), 375.8 bits, see alignment E=1.6e-116 PF01566: Nramp" amino acids 54 to 412 (359 residues), 451.5 bits, see alignment E=1.1e-139

Best Hits

Swiss-Prot: 72% identical to MNTH1_PSEAE: Divalent metal cation transporter MntH 1 (mntH1) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K03322, manganese transport protein (inferred from 99% identity to pfs:PFLU2457)

Predicted SEED Role

"Manganese transport protein MntH" in subsystem Transport of Manganese

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7U2R5 at UniProt or InterPro

Protein Sequence (440 amino acids)

>PS417_11460 divalent metal cation transporter MntH (Pseudomonas simiae WCS417)
MKFSLPKIATAPFCPPEVAGSVAVDPKASFFKRALMFAGPGLLISIGYMDPGNWATAIEA
GSRYGYNLLFVVLLASLAGMAVQCLCSRLGIATGKDLAQLCRERYSRRSARTQWVLAEIS
IVATDLAEVLGCALAFHLLLGVSLTTGIVITAFDTLLILALQNRGFRRLEAIMLALVATI
GVCFFIELVLIKPYWPDVFSGFTPSLSAISDAAPLYLAIGILGATVMPHNLYLHSSIVQT
RLIGKDLASKQDAVKLARIDTIGSLALALLVNAAILVLAAAAFHKTGHTDVVEIQDAYHL
LDPLVGGAFASILFGIALLASGQSSTFTGTIAGQVIMEGYLNLRIPCWQRRLITRGLALI
PAFLGVWLMGDDAIGKLLILSQVVLSLQLPFALYPLIRMTGDKQLMGPFVNRLPTRLLAW
FLFALISGANAWLIGQWVFG