Protein Info for GFF2237 in Sphingobium sp. HT1-2

Annotation: predicted 2-keto-3-deoxyxylonate dehydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 382 PF01557: FAA_hydrolase" amino acids 164 to 348 (185 residues), 25 bits, see alignment E=6.8e-10

Best Hits

KEGG orthology group: None (inferred from 83% identity to sjp:SJA_C1-12880)

Predicted SEED Role

"Fumarylacetoacetate hydrolase family protein" in subsystem Gentisare degradation or Salicylate and gentisate catabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (382 amino acids)

>GFF2237 predicted 2-keto-3-deoxyxylonate dehydratase (Sphingobium sp. HT1-2)
MPGDTALLDCLPHDWRTGLFLGRIQTNAGPSPILVSQGIVYDMSAIAPTSAQLVEKLPFV
AATDGEKIGDLDAIEAALLSPVDLQCVKACGVTFALSALERVIEERARGDAGAAAEIRGR
LEERVGGSIRAVVPGTEEAAALKAALIEDGLWSQYLEVAIGPDAEVFTKAPVLATVGPMA
EIGIRSDSTWNNPEPEVVLLVNADGQAVGATLGNDVNLRDFEGRSALLLGKAKDNNASCS
LGPLVRLFDGDFTIDDVRNAEVGLTIEGPEGYMLEGTSRMDQISRDPLELVRQTLSEHQY
PDGFALFLGTLFAPVQDRDEEGRGFTHKVGDIVAISTPRLGKLINPVVTSKDAAPWTFGL
TALMTNLAGRGLLSAVDQKETA