Protein Info for GFF2224 in Xanthobacter sp. DMC5

Annotation: 4-hydroxy-tetrahydrodipicolinate reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00036: 4-hydroxy-tetrahydrodipicolinate reductase
  • amino acids 4 to 271 (268 residues), 269.5 bits, E=1.7e-84
• PF01113: DapB_N
  • amino acids 5 to 127 (123 residues), 120 bits, E=6.6e-39
• PF05173: DapB_C
  • amino acids 130 to 270 (141 residues), 142.9 bits, E=5.2e-46

Best Hits

Swiss-Prot: 63% identical to DAPB_RHOPS: 4-hydroxy-tetrahydrodipicolinate reductase (dapB) from Rhodopseudomonas palustris (strain BisB5)

KEGG orthology group: K00215, dihydrodipicolinate reductase [EC: 1.3.1.26] (inferred from 81% identity to xau:Xaut_0359)

MetaCyc: 48% identical to 4-hydroxy-tetrahydrodipicolinate reductase (Escherichia coli K-12 substr. MG1655)
RXN-14014 [EC: 1.17.1.8]

Predicted SEED Role

"4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8)" (EC 1.17.1.8)

MetaCyc Pathways

• aspartate superpathway (22/25 steps found)
• L-lysine biosynthesis I (9/9 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (15/18 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (12/15 steps found)
• L-lysine biosynthesis III (6/7 steps found)
• L-lysine biosynthesis VI (6/7 steps found)
• L-lysine biosynthesis II (7/9 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Lysine biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.17.1.8 or 1.3.1.26

Protein Sequence (275 amino acids)

>GFF2224 4-hydroxy-tetrahydrodipicolinate reductase (Xanthobacter sp. DMC5)
VTDLRIVIAGAGGRMGRTLIRAIAESEGLKLVGALEYSGSAHLGEDAGLMAGAGPNGVTV
ESDVAPSLNGADVVIDFSTPAATVRLAGRLAEAGIAHVIGTTGLSNEDNAAIADAALRTV
IVKSGNMSLGVNLLAALTRRVAATLGDDFDIEIVEMHHNRKVDAPSGTALLLGEAAAAGR
NRKLDDCSERGRDGITGPRVKGNIGFASLRGGSVVGEHMVIFAGTSERIELVHKAEDRAL
FANGALVAARWTKCGETKREPGLYSMADVLGLADF