Protein Info for GFF2221 in Sphingobium sp. HT1-2

Annotation: Proline dehydrogenase (EC 1.5.5.2) / Delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.2.1.88)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1208 PF18327: PRODH" amino acids 18 to 65 (48 residues), 74.4 bits, see alignment (E = 1.4e-24) PF14850: Pro_dh-DNA_bdg" amino acids 73 to 184 (112 residues), 149.6 bits, see alignment E=9.1e-48 PF01619: Pro_dh" amino acids 193 to 491 (299 residues), 343.6 bits, see alignment E=2e-106 TIGR01238: delta-1-pyrroline-5-carboxylate dehydrogenase" amino acids 529 to 1022 (494 residues), 708.6 bits, see alignment E=2e-217 PF00171: Aldedh" amino acids 578 to 1021 (444 residues), 338.5 bits, see alignment E=1.1e-104

Best Hits

KEGG orthology group: K13821, proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase [EC: 1.5.1.12 1.5.99.8] (inferred from 65% identity to aaa:Acav_1933)

Predicted SEED Role

"Proline dehydrogenase (EC 1.5.99.8) (Proline oxidase) / Delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12)" in subsystem Arginine and Ornithine Degradation or Proline, 4-hydroxyproline uptake and utilization or Respiratory dehydrogenases 1 (EC 1.5.1.12, EC 1.5.99.8)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.5.99.8

Use Curated BLAST to search for 1.5.1.12 or 1.5.99.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1208 amino acids)

>GFF2221 Proline dehydrogenase (EC 1.5.5.2) / Delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.2.1.88) (Sphingobium sp. HT1-2)
MTDQHPFAAFAPAIRDQSPLRQAITAAYRRDEAECLAPLLDAATLPDATRAAVADTARHL
VTTLRANHKGTGVEGLVQEYSLSSQEGVALMCLAEALLRIPDNDTRVALIRDKIADGDWS
SHLGGGKSLFVNAATWGLVVTGKLVGSVDDRGLAAALARLVARAGEPVIRRGVDLAMRMM
GEQFVTGETIKEAVKRAKELEAKGFAYSYDMLGEAATTAADAARYYADYEKAIHAIGKAS
AGRGIYAGPGISIKLSALHPRYVRAQADRVMGELLPAVKQLALLSKRYDIGLNIDAEEAD
RLELSLDLLESLALDPELAGWDGLGFVVQGYGKRCPFVIDWIIDLARRANRRMMVRLVKG
AYWDAEIKRAQVDGLADFPVYTRKVHTDVAYVACAKKLLAAPDAVFPQFATHNAQTLATI
YQMAGPDFAIGKYEFQCLHGMGEPLYEQVVGKDKLDRPCRIYAPVGTHETLLAYLVRRLL
ENGANSSFVNRIADPDVSIEEMIADPVEIVRAMPHPGARHDQIAAPVGLYPDRRNSDGID
LSDEGALAALTQALQHSATIAWTAAPEGGEGPEGGEGEARPVCNPADHRDIVGTVWEASA
DHARAAAIRAANACWPNTAVADRAAMLDRAADAMQERMPVLLGLIMREAGKSLPNAIAEV
REAIDFLRYYAAQARGTFGPDQAPLGPIICISPWNFPLAIFTGQVAAALVAGNPVLAKPA
EETPLIAAEAVRLLHDAGVPGDALQLLPGDGRIGAALVAAPETAGVMFTGSTEVARLIQR
QLATRLSPAGKPIPLIAETGGQNAMIVDSSALAEQVVADVIASAFDSAGQRCSALRILCL
QEDVADRTLTMLKGALRELRIGRTDRLAVDTGPVITAEAKAGIEQHIASMRALGRKVEQQ
KLPEEAAHGTFVAPTIIELDSIVDLSREIFGPVLHVIRFRRERMDALVDAINATGYGLTF
GLHTRLDETVARVIARVKAGNIYVNRNVIGAIVGVQPFGGRGLSGTGPKAGGPLYLGRLT
RTAPVFAERVGYLASPIHDFVSWLEAQDDHEAAAVARHYGDASALGVELALPGPVGETNL
YALHPRGLLLLRPGTRRGLLAQMAAVLATGNRAVIEGAPLPQGLPASVAAHFLVQPDAPF
AAMLVEGDADQILAATQAVAELDGPIVTVHAAAPGDERAWHLDWLLEEVSTSINTTAAGG
NASLMMIG