Protein Info for GFF2213 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Periplasmic thiol:disulfide interchange protein DsbA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 207 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details PF01323: DSBA" amino acids 40 to 196 (157 residues), 108.7 bits, see alignment E=3.3e-35 PF13462: Thioredoxin_4" amino acids 40 to 185 (146 residues), 40.8 bits, see alignment E=2.6e-14

Best Hits

Swiss-Prot: 100% identical to DSBA_SALEN: Thiol:disulfide interchange protein DsbA (dsbA) from Salmonella enteritidis

KEGG orthology group: K03673, thiol:disulfide interchange protein DsbA (inferred from 99% identity to ses:SARI_03663)

MetaCyc: 86% identical to thiol:disulfide oxidoreductase DsbA (Escherichia coli K-12 substr. MG1655)
RXN-21426 [EC: 1.8.4.15]; 1.8.4.15 [EC: 1.8.4.15]

Predicted SEED Role

"Periplasmic thiol:disulfide interchange protein DsbA" in subsystem Biogenesis of c-type cytochromes or Periplasmic disulfide interchange

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.8.4.15

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (207 amino acids)

>GFF2213 Periplasmic thiol:disulfide interchange protein DsbA (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MKKIWLALAGMVLAFSASAAQISDGKQYITLDKPVAGEPQVLEFFSFYCPHCYQFEEVLH
VSDNVKKKLPEGTKMTKYHVEFLGPLGKELTQAWAVAMALGVEDKVTVPLFEAVQKTQTV
QSAADIRKVFVDAGVKGEDYDAAWNSFVVKSLVAQQEKAAADLQLQGVPAMFVNGKYQIN
PQGMDTSSMDVFVQQYADTVKYLVDKK