Protein Info for GFF2177 in Xanthobacter sp. DMC5

Annotation: Putative L-lactate dehydrogenase operon regulatory protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 252 PF00392: GntR" amino acids 5 to 63 (59 residues), 65.4 bits, see alignment E=3e-22 PF07729: FCD" amino acids 91 to 217 (127 residues), 73.6 bits, see alignment E=2e-24

Best Hits

KEGG orthology group: K05799, GntR family transcriptional regulator, transcriptional repressor for pyruvate dehydrogenase complex (inferred from 63% identity to xau:Xaut_3930)

Predicted SEED Role

"Lactate-responsive regulator LldR in Enterobacteria, GntR family" in subsystem Lactate utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (252 amino acids)

>GFF2177 Putative L-lactate dehydrogenase operon regulatory protein (Xanthobacter sp. DMC5)
LADLTDTIEALIAERGLQPGARLPAERALAAELNVSRPTLREAIRHLASRGRLVSRRGGG
TYVAAPADAPLAQALGPLAAEAAGEPGYWHDVMEIRKSLDADMAFHAALRAGPQDKANLQ
AALENVISAGATDAATQAKADSAFHMAVAEASHNAVMRQVMAGLFDLLRHSISRSLEKLY
LIASTAQALDDQHRAIAAAIIAGRPEEARKAALLHLEFVEETLREIEDDAARRRRSSRVA
QRQNQQEKELTP