Protein Info for GFF2170 in Xanthobacter sp. DMC5

Annotation: Aldehyde oxidoreductase molybdenum-binding subunit PaoC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01315: Ald_Xan_dh_C
  • amino acids 36 to 136 (101 residues), 79 bits, E=5.2e-26
• PF02738: MoCoBD_1
  • amino acids 165 to 388 (224 residues), 191.3 bits, E=2.4e-60
• PF20256: MoCoBD_2
  • amino acids 414 to 673 (260 residues), 187.7 bits, E=4.9e-59

Best Hits

Swiss-Prot: 69% identical to PAOC_ECOLI: Aldehyde oxidoreductase molybdenum-binding subunit PaoC (paoC) from Escherichia coli (strain K12)

KEGG orthology group: K11177, xanthine dehydrogenase YagR molybdenum-binding subunit [EC: 1.17.1.4] (inferred from 77% identity to sno:Snov_0396)

MetaCyc: 69% identical to aldehyde dehydrogenase, molybdenum cofactor-binding subunit (Escherichia coli K-12 substr. MG1655)
Carboxylate reductase. [EC: 1.2.99.6]; 1.2.98.- [EC: 1.2.99.6]; 1.2.98.- [EC: 1.2.99.6]

Predicted SEED Role

"Periplasmic aromatic aldehyde oxidoreductase, molybdenum binding subunit YagR"

MetaCyc Pathways

• adenosine nucleotides degradation II (4/5 steps found)
• guanosine nucleotides degradation II (3/4 steps found)
• guanosine nucleotides degradation III (3/4 steps found)
• inosine 5'-phosphate degradation (3/4 steps found)
• purine nucleotides degradation II (aerobic) (8/11 steps found)
• adenosine nucleotides degradation I (5/8 steps found)
• guanosine nucleotides degradation I (2/4 steps found)
• ureide biosynthesis (4/7 steps found)
• purine nucleobases degradation II (anaerobic) (16/24 steps found)
• superpathway of guanosine nucleotides degradation (plants) (3/6 steps found)
• purine nucleotides degradation I (plants) (7/12 steps found)
• superpathway of purines degradation in plants (9/18 steps found)
• caffeine degradation III (bacteria, via demethylation) (1/7 steps found)
• theophylline degradation (1/9 steps found)
• caffeine degradation IV (bacteria, via demethylation and oxidation) (1/10 steps found)

KEGG Metabolic Maps

• Purine metabolism
• Pyruvate metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.17.1.4

Use Curated BLAST to search for 1.17.1.4 or 1.2.99.6

Protein Sequence (737 amino acids)

>GFF2170 Aldehyde oxidoreductase molybdenum-binding subunit PaoC (Xanthobacter sp. DMC5)
MKFETPAADNPIDQLKIIGQPVSRIDGPFKTTGTAPYAYERHDVAPNAAHGFVVGATIAR
GRITGIDTAAAEAAPGVVTVVTAANAGPLKKGSNNTALLLAGPEVEHYHQAVALVVADTF
EQARAAAVLVKVDYAPAAGAFDLGKAMDSAVKPEKGDGQGGPADTAVGDFNGAFAAAPIR
LDATYSTPDQSHAMMEPHASTAAWEGDRLTVWTSNQMIEWGRSDLAKMLGLPKDRVRMIS
PYIGGGFGGKLFVRADAMLAALGARAARRPVKVALHRHLVINNTTHRPATIQRIRIGAGR
DGRITAIGHESWSGDLPGGGLETAVNQTRLLYAGAHRLTAMRLATLDLPEGNAMRAPGEA
PGLMALEIAMDEMAEKLNLDPVEFRVLNDTERDPENPDRPFSQRQLVACLRLGAERFGWS
RRNPKPGQVRDGDQLIGMGMAVGFRNNLLMKSGARVRLDGEGRVTVETAMTDIGTGSYTI
LAQTAAEMMGVPLDKVRVVLGDSSLPASCGSGGQWGANNATSGVYAACMKLREDVARKLG
FNSKEAVFAEGEVRAGNRSVPLAQAAGDEGLTAEDTIEYGDLAKRYQQSTFAGHFVEMAV
DAATGEARVRRMLAVCAAGRILNPKTARSQVIGAMTMGVGAALFEELAVDTRHGFFVNHD
LVGYEVPVHADIPHQEVIFLDEADPISSPMKAKGVGELGLCGVGAAVANALYNATGVRVR
DYPITLDKYIHRLPEVG