Protein Info for GFF2163 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Phosphonate ABC transporter ATP-binding protein (TC 3.A.1.9.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 276 TIGR02315: phosphonate ABC transporter, ATP-binding protein" amino acids 1 to 240 (240 residues), 323.7 bits, see alignment E=3.5e-101 PF00005: ABC_tran" amino acids 17 to 172 (156 residues), 124.3 bits, see alignment E=5.8e-40

Best Hits

Swiss-Prot: 52% identical to PHNC_LACJO: Phosphonates import ATP-binding protein PhnC (phnC) from Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)

KEGG orthology group: K02041, phosphonate transport system ATP-binding protein (inferred from 84% identity to vpe:Varpa_2140)

Predicted SEED Role

"Phosphonate ABC transporter ATP-binding protein (TC 3.A.1.9.1)" in subsystem ABC transporter alkylphosphonate (TC 3.A.1.9.1) (TC 3.A.1.9.1)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (276 amino acids)

>GFF2163 Phosphonate ABC transporter ATP-binding protein (TC 3.A.1.9.1) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MIEIRNLTKRYGDFVALHDVSLSVAKGEFVVILGASGAGKSTLLRCINHLAEPSGGEIRV
DGELSRGDRAGLRKVRRDVAMIFQHYNVVPRLSVLKNVLTGRLGSMPALMSWFQLFPRED
IDAARECLRRVELEHKADVRTDTLSGGQKQRVGIARALAQHPKVILADEPVASLDPKTSR
KVLRYLQQASRDSGITVICNLHQVDYAREFGQRVIGVAGGRIVFEGRPDELSDEVLQRIY
PGGLEGPTPPEAPAASVAVPSPVAAHAAPQLALEQP