Protein Info for GFF2159 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Exodeoxyribonuclease VII large subunit (EC 3.1.11.6)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 449 PF13742: tRNA_anti_2" amino acids 10 to 103 (94 residues), 115.6 bits, see alignment E=1.5e-37 TIGR00237: exodeoxyribonuclease VII, large subunit" amino acids 11 to 358 (348 residues), 467.3 bits, see alignment E=2.3e-144 PF01336: tRNA_anti-codon" amino acids 30 to 104 (75 residues), 51.6 bits, see alignment E=1.1e-17 PF02601: Exonuc_VII_L" amino acids 126 to 440 (315 residues), 384.1 bits, see alignment E=9.3e-119

Best Hits

Swiss-Prot: 100% identical to EX7L_SALTY: Exodeoxyribonuclease 7 large subunit (xseA) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K03601, exodeoxyribonuclease VII large subunit [EC: 3.1.11.6] (inferred from 100% identity to stm:STM2512)

MetaCyc: 88% identical to exodeoxyribonuclease VII subunit XseA (Escherichia coli K-12 substr. MG1655)
Exodeoxyribonuclease VII. [EC: 3.1.11.6]

Predicted SEED Role

"Exodeoxyribonuclease VII large subunit (EC 3.1.11.6)" in subsystem DNA repair, bacterial (EC 3.1.11.6)

Isozymes

Compare fitness of predicted isozymes for: 3.1.11.6

Use Curated BLAST to search for 3.1.11.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (449 amino acids)

>GFF2159 Exodeoxyribonuclease VII large subunit (EC 3.1.11.6) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MLSSQTSSIFTVSRLNQTVRLLLEQEMGQVWISGEISNFTQPASGHWYFTLKDDTAQVRC
AMFRNSNRRVTFRPQHGQQVLVRANITLYEPRGDYQIIAESMQPAGEGLLQQKYEQLKAK
LQAEGLFDQQHKQPLPSPAHCVGVITSKTGAALHDILHVLKRRDPSLPVIIYPTAVQGDD
APGQIVRAIELANARGECDVLIVGRGGGSLEDLWSFNDERVARAIFASRIPVVSAVGHET
DVTIADFVADLRAPTPSAAAEIVSRNQQELLRQIQSAQQRLGMAMDYYLANRSRRFTQIF
HRLQQQHPQLRLARQQTALERLRQRMGFALEARIKQANQRQQCVSQRLSQQNPQPRIHRA
QSRIQQLEYRLTENIRSRLSEQRERFGNAVTHLEAVSPLATLARGYTVSTTTDGKVLKKI
KQVKAGDIMTTRLEDGWLESEVKSVTPGT