Protein Info for PS417_10960 in Pseudomonas simiae WCS417

Annotation: quinate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 802 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 40 to 60 (21 residues), see Phobius details amino acids 67 to 90 (24 residues), see Phobius details amino acids 96 to 114 (19 residues), see Phobius details amino acids 121 to 141 (21 residues), see Phobius details TIGR03074: membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family" amino acids 18 to 802 (785 residues), 1093.8 bits, see alignment E=0 PF13360: PQQ_2" amino acids 219 to 385 (167 residues), 22.3 bits, see alignment E=9.7e-09 PF01011: PQQ" amino acids 223 to 251 (29 residues), 29.6 bits, see alignment (E = 4e-11) amino acids 450 to 476 (27 residues), 25.8 bits, see alignment (E = 6.3e-10)

Best Hits

Swiss-Prot: 65% identical to QUIA_ACIAD: Quinate/shikimate dehydrogenase (quinone) (quiA) from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

KEGG orthology group: K05358, quinate dehydrogenase (quinone) [EC: 1.1.5.8] (inferred from 97% identity to pfs:PFLU2304)

MetaCyc: 65% identical to quinate/shikimate dehydrogenase (quinone) (Acinetobacter baylyi ADP1)
1.1.99.25-RXN [EC: 1.1.5.8]; 1.1.5.8 [EC: 1.1.5.8]

Predicted SEED Role

"Quinate/shikimate dehydrogenase [Pyrroloquinoline-quinone] (EC 1.1.99.25)" in subsystem Chorismate Synthesis or Quinate degradation (EC 1.1.99.25)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.5.8 or 1.1.99.25

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7UGG7 at UniProt or InterPro

Protein Sequence (802 amino acids)

>PS417_10960 quinate dehydrogenase (Pseudomonas simiae WCS417)
MKRASRAAGVSRLLLLGLGVIIALLGLALAIGGVKLVSLGGSWYFLIGGAIMAIAGLLIA
CRKPAGAWVFAAFLIGTAIWAVADVGLVFWPLFSRLFMFAAIGMVVALVYPLLVNKPARG
AYAVAAVLAAGVAVAAGNMFVAHPSVAPTGAGPGITPVAAGDAQKDWAHYGNTEGGSRFA
ALDQINRDTVNKLKVAWTYHTGDVAISDGNGAEDQLTPLQIGNKVFICTPHNNLIALDAD
TGKELWKNEVNAKSAVWQRCRGMAYFDATAPIAQPTQPNSSPIMPASVPAGAQCQRRLLT
NTIDARLIAVDADTGKFCEDFGTHGQVDLKAGLGNVPDSYYQLSSAPLIAGTTVVVGGRV
ADNVQTDMPGGVIRGFDVISGQMRWAFDPGNPEDKQAPADGSTYVRSTPNSWAPMSYDPL
MNTVFLPMGSSSTDIYGVERTQLNHKYGASVLALDASTGAEKWVYQTVHNDLWDFDLPMQ
PSLIDFTPPGSDKAVPAVVIGTKAGQIYVLDRATGKPLTDVQEVPVKAANIPNEPYSPTQ
PKSVGMPQIGAQTLTESDMWGATPFDQLLCRIDFKGMRYEGLYTAPGTDKSLSFPGSLGG
MNWGSISTDPVHGFIFVNDMRLGLWIQMVPSQNKAQASSGGEALNTGMGAVPLKGTPYAV
NKNRFLSVAGIPCQAPPFGTLTAIDMKTQKVAWQVPVGTVEDTGPLGIRMHLPIKIGLPT
LGGTLSTQGGLIFIAGTQDFYLRAFNSGNGDEVWKARLPVGSQGGPMTYVSPKTGKQYIV
ITAGGARQSTDRGDYVIAYALP