Protein Info for GFF2137 in Xanthobacter sp. DMC5

Annotation: Vitamin B12 transporter BtuB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1136 signal peptide" amino acids 1 to 62 (62 residues), see Phobius details TIGR01785: TonB-dependent heme/hemoglobin receptor family protein" amino acids 152 to 849 (698 residues), 320.6 bits, see alignment E=1.1e-99 PF07715: Plug" amino acids 167 to 273 (107 residues), 59.1 bits, see alignment E=8.7e-20 PF00593: TonB_dep_Rec_b-barrel" amino acids 411 to 823 (413 residues), 127.4 bits, see alignment E=2.2e-40 PF13505: OMP_b-brl" amino acids 875 to 1077 (203 residues), 40.4 bits, see alignment E=5.5e-14

Best Hits

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1136 amino acids)

>GFF2137 Vitamin B12 transporter BtuB (Xanthobacter sp. DMC5)
MGSKRFHAMWMSGRFGQAPCGEARLGAVKASRAPARMLAGALMGATGLGAALLSMPGVAK
AQVAREVTFNIPAGPLSGALAAFGRQSGVQITYAPELAVGKSSPGVTGTVSLSAAMGRIL
QETGLSHAFVGPNTVAITGTATGAFADGTHVLDTIEVTSASPVDRPFETPGTTNFISGEE
LERFPGLTAGSIFQGTPGVISGSSNNGAAIDPNIRGLQGMNRVATTIDGSQQSSSSYRGY
AGVSSRTFVDPDLISGITVTKGPDGAVGGAIGGIIAMDTLGITDILKPGDTYGVRARMGL
NSNGTTPLIGAKAADFGHSDADNWSGSFAAAVTTPNVDLVAAYVQRQSGNYFAGTQGDLT
TENYLGKQVRLSNYYYGQQVYNTSEDVASGLLKATVRPADGHELQLSYLYYGNDFGEVTP
SAIAVGTNVTWQIPLSSVALNQATARYHYKPDGNELVDFKVNAYGSNIDEVTVFTLAKDT
TKIKQQTQNAGISAENTSRFLLASTPISLRYGGTYALEVARPNFPINPEDFSGWAVPADA
DREIGTLFARAKLEPLSWLTLEAGLEYLTYETTFNGTSFEYIGPEFTSYSGSGVSPTVSA
TVTPLPGWQLYAQYSTGIRPPSTREVSQTRNDQRFNPTLQAENAVNYEVGTNLLKSDVFL
PGDKLRAKVAYFDNTTNNYIGRQFSINMSLFNYDYVRFKGAEFSGGYDAGPAFVDFGFNY
YTDFEACLLNGQCMSYTPQADYLANQVPPRFTASVTAGMRFWDDRVTLGGRLTYMGQRLA
PLVADPSYFSTIAKNWAPYTIVDLFGQWKINDTLTFDVSVQNLLDAYYVDALNNTDMPAP
GRVIRGSLTAKLGGAEPVSRLPFGRPASNRNMPWSGLYAGGFFGYGIGQISGTTTLLDGN
ANPVAASESADQSLSGVQGGVQGGYNHQFSNGFVLGLEGDFAWMRLASTRQTRTQEGPIL
IAANMLEASTEYSFDWLSTVRARAGYGWDRLMVYATGGVAFLREEEERTQYRSTTASGLQ
PSGYRTVPFFTEVAANTRTGFAVGGGAEYAISDNWSITGSYLYAGFGAEEFLFTDARAGV
TRGYTVSCTPGNRTPPCPGGKRAIIKVPGTSETVNGRDASNSANLQLLKIGVNYRF