Protein Info for GFF2109 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Sigma factor RpoE negative regulatory protein RseB precursor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 318 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details PF03888: MucB_RseB" amino acids 29 to 204 (176 residues), 203 bits, see alignment E=2.9e-64 PF17188: MucB_RseB_C" amino acids 217 to 313 (97 residues), 103.2 bits, see alignment E=6.7e-34

Best Hits

Swiss-Prot: 100% identical to RSEB_SALT1: Sigma-E factor regulatory protein RseB (rseB) from Salmonella typhimurium (strain 14028s / SGSC 2262)

KEGG orthology group: K03598, sigma-E factor negative regulatory protein RseB (inferred from 98% identity to ses:SARI_00285)

Predicted SEED Role

"Sigma factor RpoE negative regulatory protein RseB precursor" in subsystem Transcription initiation, bacterial sigma factors

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (318 amino acids)

>GFF2109 Sigma factor RpoE negative regulatory protein RseB precursor (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MKQLWFAMSLVAASLFFSANASADPASGALLQQMNIASQSLNYELSFVSITKQGVESLRY
RHARLDGRPLAQLLQLDGPRREVVQRGNEISYFEPGLEPFTLNGDYIVDSLPSLIYTDFK
RLAPYYDFISVGRTRIADRLCEVIRVVARDGTRYSYIVWMDMDTKLPMRVDLLDRDGETL
EQFRVIAFTVSQDIGSNMQALAKANLPPLLSVPGGEKTKFNWSPSWVPQGFSEVSSSRRP
LPTMDNLPIESRLYSDGLFSFSVNVNRATQNSSDQMLRTGRRTVYSSVRDNAEITIVGEL
PPQTAKRIADSIKFRAVQ