Protein Info for GFF2101 in Xanthobacter sp. DMC5

Annotation: Multicopper oxidase MmcO

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 485 signal peptide" amino acids 1 to 37 (37 residues), see Phobius details PF07732: Cu-oxidase_3" amino acids 54 to 138 (85 residues), 25.5 bits, see alignment E=1.8e-09 PF00394: Cu-oxidase" amino acids 234 to 316 (83 residues), 35.6 bits, see alignment E=1.5e-12 PF07731: Cu-oxidase_2" amino acids 376 to 484 (109 residues), 99.8 bits, see alignment E=1.7e-32

Best Hits

Predicted SEED Role

"Multicopper oxidase" in subsystem Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (485 amino acids)

>GFF2101 Multicopper oxidase MmcO (Xanthobacter sp. DMC5)
MTRPMPIPRLSRRAFLAGGAAAGALAVSGGWNRAFAAPLLTVESLTLDVNGKAAKVFAVK
GPAGEGIFAKEGDRLSGAVLNASNTPAVIHWHGQVFAPPDQDRARPDGGELGPGGTDQVD
FPLTPGTHWMHSHTLSEQQLLAAPLVTREADTGDVQDVVVMLHDFSFRSPQEILAGLGGS
SAHGSHGMGGTMQGMPGMAMPGMNHSGHDMSGMGGGMMTHANDVDYDAFLANRRTLGDPE
VVRVDKGGRVRLRIINGGTATAFFISAPGLSPRCIAVDGVPCAPLLAEAFPLAQGQRIDL
MVEIPAGGGAFPVLAQVEASPRRTGLVLATAGASVPRIPETAERPQGLLDLDFEARLFAG
KPLPRRRADKVFPIMLGEEAGYRWTINGRTHAEAEPFVVSPGERVEMTFMNPTGMSHPMH
LHGHHFQVVGLGGKRFPGAVRDTVMVPPHMPVTIAFDAGPKGEWFLHCHHLYHMATGMMA
VLKVA