Protein Info for GFF2095 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: CDP-diacylglycerol--serine O-phosphatidyltransferase (EC 2.7.8.8)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00614: PLDc
  • amino acids 134 to 159 (26 residues), 24.9 bits, see alignment (E = 1.6e-09)
  • amino acids 353 to 379 (27 residues), 33.1 bits, see alignment (E = 4.1e-12)
• PF13091: PLDc_2
  • amino acids 259 to 405 (147 residues), 54.3 bits, E=1.2e-18

Best Hits

Swiss-Prot: 94% identical to PSS_ECOLI: CDP-diacylglycerol--serine O-phosphatidyltransferase (pssA) from Escherichia coli (strain K12)

KEGG orthology group: K00998, phosphatidylserine synthase [EC: 2.7.8.8] (inferred from 100% identity to sei:SPC_2764)

MetaCyc: 94% identical to phosphatidylserine synthase (Escherichia coli K-12 substr. MG1655)
CDP-diacylglycerol--serine O-phosphatidyltransferase. [EC: 2.7.8.8]

Predicted SEED Role

"CDP-diacylglycerol--serine O-phosphatidyltransferase (EC 2.7.8.8)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 2.7.8.8)

MetaCyc Pathways

• superpathway of phospholipid biosynthesis III (E. coli) (12/12 steps found)
• superpathway of cardiolipin biosynthesis (bacteria) (11/13 steps found)
• phosphatidylserine and phosphatidylethanolamine biosynthesis I (2/2 steps found)
• cardiolipin and phosphatidylethanolamine biosynthesis (Xanthomonas) (3/4 steps found)
• superpathway of phospholipid biosynthesis II (plants) (10/28 steps found)

KEGG Metabolic Maps

• Glycerophospholipid metabolism
• Glycine, serine and threonine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.8.8

Protein Sequence (451 amino acids)

>GFF2095 CDP-diacylglycerol--serine O-phosphatidyltransferase (EC 2.7.8.8) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MLSKFKRNKHQQHLAQLPKISQSVDDVDFFYTPATFRETLLEKIASATQRICIVALYLEQ
DDGGKGILDALYAAKRQRPELDVRVLVDWHRAQRGRIGAAASNTNADWYCRLAQENPGID
VPVYGVPINTREALGVLHFKGFIIDDSVLYSGASLNDVYLHQHDKYRYDRYQLIRNRQMA
DIMFDWVTQNLMNGRGVNRLDNTQRPKSPEIKNDIRLYRQELRDASYHFQGDANDEQLSV
TPLVGLGKSSLLNKTIFHLMPCAEHKLTICTPYFNLPAVLVRNIIQLLRDGKKVEIIVGD
KTANDFYIPEDEPFKIIGALPYLYEINLRRFLSRLQYYVNTDQLVVRLWKDDDNTYHLKG
MWVDDKWMLLTGNNLNPRAWRLDLENAILIHDPKQELAPQREKELELIRTHTTIVKHYRD
LQSIADYPIKVRKLIRRLRRIRIDRLISRIL