Protein Info for GFF2078 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Acetaldehyde dehydrogenase, ethanolamine utilization cluster (EC 1.2.1.10)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 34 to 422 (389 residues), 109.3 bits, E=9.1e-36

Best Hits

Swiss-Prot: 100% identical to EUTE_SALTY: Ethanolamine utilization protein EutE (eutE) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K04021, aldehyde dehydrogenase (inferred from 100% identity to sec:SC2459)

MetaCyc: 100% identical to acetaldehyde dehydrogenase (acetylating) (Salmonella enterica enterica serovar Typhimurium str. LT2)
Acetaldehyde dehydrogenase (acetylating). [EC: 1.2.1.10]

Predicted SEED Role

"Acetaldehyde dehydrogenase, ethanolamine utilization cluster (EC 1.2.1.10)" (EC 1.2.1.10)

MetaCyc Pathways

• superpathway of N-acetylneuraminate degradation (22/22 steps found)
• mixed acid fermentation (16/16 steps found)
• hexitol fermentation to lactate, formate, ethanol and acetate (18/19 steps found)
• superpathway of L-threonine metabolism (17/18 steps found)
• superpathway of fermentation (Chlamydomonas reinhardtii) (9/9 steps found)
• heterolactic fermentation (15/18 steps found)
• superpathway of purine deoxyribonucleosides degradation (7/7 steps found)
• superpathway of pyrimidine deoxyribonucleosides degradation (6/6 steps found)
• ethanolamine utilization (5/5 steps found)
• 2-aminoethylphosphonate degradation I (3/3 steps found)
• 2-deoxy-α-D-ribose 1-phosphate degradation (3/3 steps found)
• 2-deoxy-D-ribose degradation I (3/3 steps found)
• pyruvate fermentation to ethanol I (3/3 steps found)
• pyruvate fermentation to ethanol III (3/3 steps found)
• L-threonine degradation IV (2/2 steps found)
• ethanol degradation I (2/2 steps found)
• acetylene degradation (anaerobic) (4/5 steps found)
• 2-hydroxypenta-2,4-dienoate degradation (1/3 steps found)
• sulfoacetaldehyde degradation IV (1/3 steps found)
• catechol degradation I (meta-cleavage pathway) (1/5 steps found)
• triethylamine degradation (1/6 steps found)
• superpathway of Clostridium acetobutylicum solventogenic fermentation (6/13 steps found)
• catechol degradation II (meta-cleavage pathway) (1/7 steps found)
• toluene degradation I (aerobic) (via o-cresol) (1/7 steps found)
• toluene degradation V (aerobic) (via toluene-cis-diol) (1/7 steps found)
• superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (8/17 steps found)
• 3-phenylpropanoate and 3-(3-hydroxyphenyl)propanoate degradation (1/8 steps found)
• p-cumate degradation (1/8 steps found)
• meta cleavage pathway of aromatic compounds (1/10 steps found)
• naphthalene degradation to acetyl-CoA (2/12 steps found)
• p-cymene degradation (1/11 steps found)
• L-tryptophan degradation IX (1/12 steps found)
• L-tryptophan degradation XII (Geobacillus) (1/12 steps found)
• toluene degradation IV (aerobic) (via catechol) (1/13 steps found)
• mandelate degradation to acetyl-CoA (2/18 steps found)
• superpathway of aerobic toluene degradation (1/30 steps found)
• superpathway of aromatic compound degradation via 3-oxoadipate (3/35 steps found)
• superpathway of aromatic compound degradation via 2-hydroxypentadienoate (4/42 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Pyruvate metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.10

Use Curated BLAST to search for 1.2.1.10

Protein Sequence (467 amino acids)

>GFF2078 Acetaldehyde dehydrogenase, ethanolamine utilization cluster (EC 1.2.1.10) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MNQQDIEQVVKAVLLKMKDSSQPASTVHEMGVFASLDDAVAAAKRAQQGLKSVAMRQLAI
HAIREAGEKHARELAELAVSETGMGRVDDKFAKNVAQARGTPGVECLSPQVLTGDNGLTL
IENAPWGVVASVTPSTNPAATVINNAISLIAAGNSVVFAPHPAAKKVSQRAITLLNQAVV
AAGGPENLLVTVANPDIETAQRLFKYPGIGLLVVTGGEAVVDAARKHTNKRLIAAGAGNP
PVVVDETADLPRAAQSIVKGASFDNNIICADEKVLIVVDSVADELMRLMEGQHAVKLTAA
QAEQLQPVLLKNIDERGKGTVSRDWVGRDAGKIAAAIGLNVPDQTRLLFVETPANHPFAV
TEMMMPVLPVVRVANVEEAIALAVQLEGGCHHTAAMHSRNIDNMNQMANAIDTSIFVKNG
PCIAGLGLGGEGWTTMTITTPTGEGVTSARTFVRLRRCVLVDAFRIV