Protein Info for GFF207 in Sphingobium sp. HT1-2
Annotation: NAD-specific glutamate dehydrogenase (EC 1.4.1.2), large form
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K00260, glutamate dehydrogenase [EC: 1.4.1.2] (inferred from 85% identity to sch:Sphch_3112)Predicted SEED Role
"NAD-specific glutamate dehydrogenase (EC 1.4.1.2), large form" in subsystem Glutamate dehydrogenases or Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis (EC 1.4.1.2)
MetaCyc Pathways
- L-alanine degradation II (to D-lactate) (3/3 steps found)
- L-glutamate degradation I (1/1 steps found)
- methylaspartate cycle (13/19 steps found)
- ethene biosynthesis IV (engineered) (1/3 steps found)
- L-glutamate degradation V (via hydroxyglutarate) (5/10 steps found)
- 4-aminobutanoate degradation V (2/7 steps found)
- L-glutamate degradation XI (reductive Stickland reaction) (2/7 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.4.1.2
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (1553 amino acids)
>GFF207 NAD-specific glutamate dehydrogenase (EC 1.4.1.2), large form (Sphingobium sp. HT1-2) MTALADPNIKEVDSTVRAALEGVLAKGALPGESEGFDQAAIAAAAAFLGRTANARKAGQP GIAIETLGEGATGRFMRIALINDDMPFLVDSIATTLAAADISIHRLLHPVLSISRGADGT LSAILDDDAPGALRESMIYIEADRADAKARRALEKALEDTLADVRVAVRDWPRMQEAMSA DANAVTDDEGAALLRWFLAGHFTQIGHELCSRVGTSEERLGICALRDKPMIAPASREAAF TWFEEGKRSPLIIKSNILSRVHRGVLLDLIILPVREGKSVTGLSIHAGMWTSAALAASPE KVPLLRSALSALMDKYGFDPAGHAGKTLAHALTTLPHDILIGFERDTLEHLALTFMSLTD RPRPKLVLATSALARHLYAFVWLPRDELSTARRVAIQDMLAKAANGPVLSWSIALEEGGL ALLRITLDLRDGGVVPDDAALDRQLKQMVRGWLPAVEEALAESEEAGRAAALAQRFAPGF PMAYRNGAGPVEAAVDIRLIHGLSGPGDKSIRIYRNPEDSAERLRLKLYSHDAIALSEVV PAFENFGFRVIDEMTTPIDGGTLGHVQRFVLELPAGGDAQAVVDRAEVVTEAIAQVIEGV AENDRFNELIVTAGFAPRAVVLFRALFRYLRQTGTAFGMATFADTLRREQGVARNLVALF EALHDPAAQDGSDKATAIQAEIDAGLEQVSSIDEDRVLRLIRAVITATLRTNFYAPAAAE ALAFKIDSALVPGLPAPLPWREIWVYSPRVEGIHLRAGPVARGGLRWSDRRDDFRTEILG LMKAQRVKNAVIVPTGAKGGFYPKQLPNPQVDRDAWFAEGTESYRIFIRTLLSITDNIVK NKVKHPAQVVVRDGDDPYFVVAADKGTATFSDVANAIALERDFWLGDAFASGGSNGYDHK AMGITAKGAWISVQRHFAEMGVDVQSEPVKVVGCGDMSGDVFGNGMLLSKAIKLVAAFDH RHIFLDPNPDPAKSWEERNRMFALPRSSWEDYDKGLISQGGGVFARSLKKIPLTPQVQEI LGVTESEMEPTALISAILKSPNDLLWFGGIGTYVKAAAQSHGDVGDPANDRLRVNAEQLR VKVVGEGANLGTTQAGRIAFSLHGGRINTDFIDNSAGVDCSDNEVNIKIALNKEMAEGRL PFDKRNALLESMTDAVGAIVLEDNRLQALGLSIAESGGAADLASYVRLIETFEETGRLDR QVEGLAANDQLLRRGQDGQGLTRPELAVLLSTAKLALQDAIEHGNLATDPSMGAELAAAF PAAMQEKEADAIAAHALKKEIIATKVANRIVNRLGIIHPFELAEEEGCSLADLASAFLIA ERLYDIRTLWADIDAADMSEAARLALFGDIASGMRAQIADILRSVPAGTLPDAGHAILAK GVETLANQVDDLLTSEALRRVTAVTDRLLSLGAPDMLAVRTAGLFKLDGAVGIAALAGRL KMDEIALTRAFTHLGEAVGIDWVQSAAARMEPTDPWERLLISGVARDMQQVRLDFLAQGK GKDVSDHVEKWLIERGARIQQFRALVQRAKAAASPNVAMLAEIAGQARGLLGR