Protein Info for GFF2040 in Variovorax sp. SCN45

Annotation: Putative drug efflux protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 416 transmembrane" amino acids 28 to 48 (21 residues), see Phobius details amino acids 60 to 83 (24 residues), see Phobius details amino acids 95 to 113 (19 residues), see Phobius details amino acids 120 to 142 (23 residues), see Phobius details amino acids 153 to 176 (24 residues), see Phobius details amino acids 182 to 203 (22 residues), see Phobius details amino acids 236 to 260 (25 residues), see Phobius details amino acids 267 to 287 (21 residues), see Phobius details amino acids 296 to 315 (20 residues), see Phobius details amino acids 321 to 344 (24 residues), see Phobius details amino acids 356 to 378 (23 residues), see Phobius details amino acids 384 to 404 (21 residues), see Phobius details PF07690: MFS_1" amino acids 34 to 370 (337 residues), 104.6 bits, see alignment E=5.4e-34 PF00083: Sugar_tr" amino acids 61 to 208 (148 residues), 35.9 bits, see alignment E=4.2e-13

Best Hits

KEGG orthology group: None (inferred from 87% identity to vpe:Varpa_5324)

Predicted SEED Role

"Putative drug efflux protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (416 amino acids)

>GFF2040 Putative drug efflux protein (Variovorax sp. SCN45)
MPSTCPELAVATADISARAKPRRLPASVAFPLLAAVLFGFFFAAAAPSPLFVVFQHAWHF
SSSLLTVAFAIYAIALLISLLVAGSLSDHIGRRPVVLGALALQAVAMGLFLLAQDIGGLI
VARVVQGIATGVASGALSAAVVEAAPASRKRLGALITSVSPLAGLALGALLTGMAVKFSV
QPVMLVFGVLAVVFALGAAVVLWMPETVTRRPGAWASLVPRVSIPARARAEFARGLPVFI
AVWALGGLFLSLAPSLMLHVFGVDNGVVNGLTVAVLSGVGAIAPTLLGRLAAPRPAIVGM
ASIAAGLVLLLASLATRSLALFFVGTAVAGVGFGGAFSALVQTLAPLAQSHERGELFAAI
FVVSYLAFSLPAMLAGFLVKPLGLLATVEGYAAVLLLIAVYGVWNQWAALRKAPGA