Protein Info for GFF2029 in Xanthobacter sp. DMC5

Annotation: Glutarate-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 27 to 485 (459 residues), 558.3 bits, E=6e-172
• TIGR01780: succinate-semialdehyde dehydrogenase
  • amino acids 38 to 483 (446 residues), 667.3 bits, E=5.5e-205

Best Hits

Swiss-Prot: 60% identical to SLAD_PSEPU: 3-sulfolactaldehyde dehydrogenase (PpSQ1_00395) from Pseudomonas putida

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 70% identity to pde:Pden_4969)

MetaCyc: 58% identical to glutarate semialdehyde dehydrogenase (Pseudomonas aeruginosa)
Glutarate-semialdehyde dehydrogenase. [EC: 1.2.1.20]

Predicted SEED Role

No annotation

MetaCyc Pathways

• L-lysine degradation X (4/6 steps found)
• 4-aminobutanoate degradation III (1/2 steps found)
• L-lysine degradation IV (2/5 steps found)
• L-lysine degradation I (3/7 steps found)
• L-lysine degradation III (1/6 steps found)
• superpathway of L-lysine degradation (13/43 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Lysine degradation
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.16

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.20

Protein Sequence (497 amino acids)

>GFF2029 Glutarate-semialdehyde dehydrogenase (Xanthobacter sp. DMC5)
MSLAAEHFLRLADPSLLVEAAFIGGQWCAADDGATFAVEDPATGKAVGTVPACGAAETRR
AIAVAETAFRSWRNVPAAERARLLERWNDLILANAADLARIMTAEQGKPLPEAEGEVRYG
ASFVKWFAEEARRIYGRTIPAPGADRRILMLEQPIGVTAAITPWNFPIAMITRKCAPALA
AGCTMVIKPSELTPFSALAVVKLAERAGIPAGVISVVTGLPAAIGEELTSNPAVRKISFT
GSTRVGAHLMRASAGTLKKLSLELGGNAPFIVFDDADLDLAVEGAMVSKFRNAGQTCVCA
NRILVQAGIHDAFVARLGERIAAQKVGPGTLPGVGIGPLINRAATEKVRAHVADALAKGA
RVAQQADTSCAEGNFVAPLLLTGATTDMLLANEETFGPVAPVFRFETESEAIAIANGTPY
GLAAYFFTEDMHRAWRVGEALEFGMVGLNTGAISMEVAPFGGVKQSGLGREGGYLGIAEY
LEPKAFHMGGLRLTAPV