Protein Info for PS417_10285 in Pseudomonas simiae WCS417

Annotation: sodium:proton antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 440 transmembrane" amino acids 20 to 40 (21 residues), see Phobius details amino acids 52 to 78 (27 residues), see Phobius details amino acids 97 to 115 (19 residues), see Phobius details amino acids 118 to 137 (20 residues), see Phobius details amino acids 146 to 171 (26 residues), see Phobius details amino acids 193 to 214 (22 residues), see Phobius details amino acids 235 to 254 (20 residues), see Phobius details amino acids 260 to 280 (21 residues), see Phobius details amino acids 292 to 311 (20 residues), see Phobius details amino acids 332 to 351 (20 residues), see Phobius details amino acids 358 to 387 (30 residues), see Phobius details amino acids 419 to 438 (20 residues), see Phobius details PF13726: Na_H_antiport_2" amino acids 3 to 86 (84 residues), 99.6 bits, see alignment E=1.4e-32 PF03553: Na_H_antiporter" amino acids 150 to 434 (285 residues), 273.8 bits, see alignment E=2.8e-85 PF06808: DctM" amino acids 184 to 390 (207 residues), 40.2 bits, see alignment E=3.1e-14

Best Hits

Swiss-Prot: 58% identical to Y2115_VIBPA: Uncharacterized membrane protein VP2115 (VP2115) from Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

KEGG orthology group: K07084, (no description) (inferred from 98% identity to pfs:PFLU2124)

Predicted SEED Role

"Histidine permease YuiF"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7UA64 at UniProt or InterPro

Protein Sequence (440 amino acids)

>PS417_10285 sodium:proton antiporter (Pseudomonas simiae WCS417)
MINAVIAAVGTMLVLSLSRVHVVIAIIVGALVGGLTGGLGIDATLKAFNGGLGGGATVAL
SYALLGAFAVAIAKSGLAHALADKALLLVDRQDASGGGHVKWLLIGLLWVVAIASQNILP
IHIAFIPLLVPPLLYVLTKLQLDRRLIACVMTFGLITPYMFLPVGFGNIFLNQILLANVA
KSGVDISQVNVTHAMSLPALGMVVGLLVAVFISYRKKRVYDLEKIERVEQVAVQYNPLTL
LVAGLAIASAFIIQLWLDSMIIGALAGFLIFSVSGIVRWRDTDDLFTEGMKMMAMIGFIM
IASSGFAEVLKATGDVRSLVETSAAFIGHNRGVGALLMLLVGLLVTMGIGSSFSTVPILA
AIFVPLCVQLGFSPVAIVCIVGTAGALGDAGSPASDSTLGPTSGLNVDGQHHHIWDTVVP
TFLHYNLPLLAFGWLAAMTL