Protein Info for GFF2009 in Xanthobacter sp. DMC5

Annotation: Glutarate-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 22 to 480 (459 residues), 476.2 bits, E=9.6e-147
• PF05893: LuxC
  • amino acids 143 to 315 (173 residues), 26.8 bits, E=2.5e-10

Best Hits

Swiss-Prot: 34% identical to BETB_XANC5: NAD/NADP-dependent betaine aldehyde dehydrogenase (betB) from Xanthomonas campestris pv. vesicatoria (strain 85-10)

KEGG orthology group: None (inferred from 80% identity to rpc:RPC_0853)

MetaCyc: 42% identical to NAD(P)+-dependent succinate semialdehyde dehydrogenase monomer (Cupriavidus necator H16)
Succinate-semialdehyde dehydrogenase (NAD(P)(+)). [EC: 1.2.1.16]; RXN-10823 [EC: 1.2.1.16]

Predicted SEED Role

"Aldehyde dehydrogenase A (EC 1.2.1.22)" in subsystem L-rhamnose utilization or Methylglyoxal Metabolism (EC 1.2.1.22)

MetaCyc Pathways

• L-lactaldehyde degradation (aerobic) (2/2 steps found)
• methylglyoxal degradation IV (2/3 steps found)
• methylglyoxal degradation V (2/3 steps found)
• 4-aminobutanoate degradation III (1/2 steps found)
• homotaurine degradation (1/2 steps found)
• superpathway of methylglyoxal degradation (5/8 steps found)
• lactate biosynthesis (archaea) (2/5 steps found)
• L-rhamnose degradation II (3/8 steps found)
• superpathway of fucose and rhamnose degradation (4/12 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Pyruvate metabolism
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.16, 1.2.1.22

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.22

Protein Sequence (487 amino acids)

>GFF2009 Glutarate-semialdehyde dehydrogenase (Xanthobacter sp. DMC5)
MNAIAPLAAQNLIDGIWQGALSGETAPSLDPATGAVLGHFPASGAADAEAAIAAARRAFE
RPEWAQAPRLRQMVMLRWADAMERKADDLARLLTAENGKPLAQSRGEIAGSVSEIRYYAG
ITRYIPGHVFEVEPGAYSTLLKEPAGVAGLIIPWNAPAVLLIRALTPALAAGCTAVVKPA
AQTALVTAEILRTLVELEGLPRGVVNLVTETGHDVARTLVASRDVDVISFTGSNATGARI
MADAAPTMKKLSLELGGKSCCLVFEDADVEAVAPKLAAAATIIAGQQCTAARRILVHESR
YEAMKAALKGALASLKIAPGAAEGSQMGPLIDEASRAQVERKTEEAMALADEVVLAGSRP
GGALEKGSFLSPTLLAHADTGAFFVQEEIFGPLVVIERFADERDAVTRANHTDYGLSASV
WTRDGARAMRVARALRNGTVWINDHNKLFAEAETGGYRRSGLGRLHGYDALIDFMEIKHI
YQEAGVV