Protein Info for GFF20 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Membrane carboxypeptidase (penicillin-binding protein)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1020 transmembrane" amino acids 34 to 53 (20 residues), see Phobius details PF00912: Transgly" amino acids 158 to 347 (190 residues), 53.7 bits, see alignment E=1.8e-18

Best Hits

KEGG orthology group: None (inferred from 69% identity to tmz:Tmz1t_0630)

Predicted SEED Role

"Membrane carboxypeptidase (penicillin-binding protein)"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1020 amino acids)

>GFF20 Membrane carboxypeptidase (penicillin-binding protein) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MEHAMSEQRMGAEPHTAHVGDPPGRQRSTAFRRFWQASLLVLLILCAAAALLVRREVQTS
HWQAQELNRYAATLKHHVAPGPADTIRFPAHGPFDERMGYTAIPGFAERLQERGFEVAEQ
SRQSEALLSHLDRGWFAPYAEKTHTGLTVFDCGREPLHAFRYPYRRFENFDGVPPVVVQA
LLFIENRDLLDPERPQMNPAVDWVRFTRAVLAQVGNRIDSDIDTHGGSTLATQIEKYRHS
PGGITHDAREKLRQMVSASVRAYQQGTDTLPVRRQLVLDYLNTVPLSAAPRHGEVHGLGD
GLWVWFGTDFESAMASLSASGDDPIARGRVLRQAVALMIAHRRPSWYLAQGREDLEHATD
AHLRLLTEAGIIDAAWRDAALAQTLVFRDMDKDPPQLPAAASKGTTAMRTRLAGLLGASL
YSLDRLDAQAGTTLNGKLQDAVSSYLGRLTDPAFASSQQLMGERMLQPGTLDEVLYSFTL
LESTPQGNLVRVQTDTTQQPLDINEGSKLELGSTAKLRVLATYLELVAELHGRLAPLDAA
ALKATTVSPQDSLGRWAVQYLSGTDDHSLATMLEAAMDRRFSANPHEPFFTGGGLHTFNN
FNKKDDARQPSLREAMQASINLPFVRLLREIVRHTLYQGPDGTARLLEDHLDPRRDTYLA
LFADREGQTFLRRFWRKTDKLTSTELRATLLDGLRPGADRLTAVFRYLEPAASPEALGAF
LSERLGDKAPDAARVAVLYQRFAPDAFDLPDRGYVARVHPLELWVVAYRLQHPRATLDEA
VAASATERQAVYKWLFRTRAKDAQDARIYTMLEVEAFLDIHRRWTRLGYPFGHLVPSLAT
ALGSSGDRPAALAELMGVIVNGGVRRPTQRISDLRFAQGTPWETALRPTPMEGERVMAPE
VARALKKALSEVVEAGTARRLAGSFQSTSGEDLSPGGKTGTGDNRVVVNKRGGLALNRTA
TFVFYLGPRHFGSVTAYVIGPNAAEHRFTSGLPVQILRSMAPVLMAHLDGGPGSGCPREP