Protein Info for GFF1972 in Sphingobium sp. HT1-2
Annotation: Homoserine kinase (EC 2.7.1.39)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 53% identical to KHSE_METRJ: Homoserine kinase (thrB) from Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831 / NBRC 15690 / NCIMB 10815 / 0-1)
KEGG orthology group: K02204, homoserine kinase type II [EC: 2.7.1.39] (inferred from 88% identity to sch:Sphch_1448)Predicted SEED Role
"Homoserine kinase (EC 2.7.1.39)" in subsystem Methionine Biosynthesis or Threonine and Homoserine Biosynthesis (EC 2.7.1.39)
MetaCyc Pathways
- aspartate superpathway (25/25 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (18/18 steps found)
- superpathway of L-isoleucine biosynthesis I (13/13 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
- superpathway of L-threonine biosynthesis (6/6 steps found)
- L-methionine biosynthesis II (5/6 steps found)
- L-threonine biosynthesis (2/2 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 2.7.1.39
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (325 amino acids)
>GFF1972 Homoserine kinase (EC 2.7.1.39) (Sphingobium sp. HT1-2) MAVYTHVPAEEIDAFLTRYDAGRLVSAKGIAEGVENSNYLLETTGHDGNGHRYILTLYEK RVDEADLPFFMDLLDHLGARGCLVPRFIADTDGKRLQQLGRRPACLIEFLTGISVTEPTP AQARACGVALGELHKAAQGFAGERRNALDKDGWHALATKCGDDFDQIAPGLGARVAEELA FLDAHWPADLPRSVIHADLFPDNVLMLGDEVTGLIDFYFSCTDIRAYDLAVTHSAWCFSN DGATWHGDRAAAIGAGYAAAHGLTDAERAAFPILCRGAALRFLLTRAYDWINTPADALVT RKDPLAYLRRMDFYAKADPAELLGA