Protein Info for GFF1942 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Beta-lactamase (EC 3.5.2.6)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 288 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details PF00144: Beta-lactamase" amino acids 41 to 241 (201 residues), 85.1 bits, see alignment E=5.4e-28 PF13354: Beta-lactamase2" amino acids 46 to 262 (217 residues), 150.9 bits, see alignment E=3.6e-48

Best Hits

Swiss-Prot: 44% identical to BLO1_KLEOX: Beta-lactamase OXY-1 (bla) from Klebsiella oxytoca

KEGG orthology group: K01467, beta-lactamase [EC: 3.5.2.6] (inferred from 60% identity to rpa:RPA0362)

MetaCyc: 38% identical to PSE-4 beta-lactamase (Pseudomonas aeruginosa)
Beta-lactamase. [EC: 3.5.2.6]

Predicted SEED Role

"Beta-lactamase (EC 3.5.2.6)" in subsystem Beta-lactamase or Tn552 (EC 3.5.2.6)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.5.2.6

Use Curated BLAST to search for 3.5.2.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (288 amino acids)

>GFF1942 Beta-lactamase (EC 3.5.2.6) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MTDRRTFCLASGAALLGLTHGNTWADTDALQDALRDIEATARGRLGVHLIDTATGREQGW
RMDERFLMLSSFKLLASALVLDRADRGEESLERRIRYRRQDLVSWSPVTERHVGGEGLSL
AQLCEATITTSDNTAANLILASYGGPGALTAYARRLGDRVTRLDRTEPELNRRAASGEPL
DTTTPRAMAHTLRALLVGDALSPASRARLLQWLLANTTGGKRLRAGVPADWRIGEKTGTA
GDDANDIGIAFPPQRAPVIVTAYLAESATDGATREAALATVGRLLARL