Protein Info for GFF1937 in Variovorax sp. SCN45

Annotation: Hemolysins and related proteins containing CBS domains

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 437 signal peptide" amino acids 1 to 18 (18 residues), see Phobius details transmembrane" amino acids 59 to 84 (26 residues), see Phobius details amino acids 94 to 116 (23 residues), see Phobius details amino acids 148 to 164 (17 residues), see Phobius details PF01595: CNNM" amino acids 5 to 196 (192 residues), 149.5 bits, see alignment E=1.3e-47 PF00571: CBS" amino acids 285 to 334 (50 residues), 27.5 bits, see alignment 4.9e-10 PF03471: CorC_HlyC" amino acids 349 to 428 (80 residues), 66.3 bits, see alignment E=2.9e-22

Best Hits

KEGG orthology group: K03699, putative hemolysin (inferred from 93% identity to vpe:Varpa_4466)

Predicted SEED Role

"Magnesium and cobalt efflux protein CorC" in subsystem Copper homeostasis: copper tolerance or Phosphate metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (437 amino acids)

>GFF1937 Hemolysins and related proteins containing CBS domains (Variovorax sp. SCN45)
MDVFLLALLTTLNAAFAMSEMALSTSRRARLAALAETGDAGAEAALKLMESPTQFLSTVQ
IGITSIGMLSGIVGEAAFAAPLAVWMESVGMGAGTASVVSTAAVVTCITFFTIIFGELVP
KRIGQLYPEPVARFVARPMRGLAKAAKPFVWLLAGATAATLKLLRIDANAARSVTEEEIS
ASLEEGVDAGVIEQHEHQMVRNVFHLDDRRLSSLMIPRADIEWLDASFTVRQALQKVADA
AALNLVHSWYPVCRNSLDDVVGVISVAHLLRLGAAHTGVLGQEATPAVFVPETLTGMELL
EQFRARAGRLVFVVDEYGVVQGLMTPRDLLEAIAGELQPGMQTDAWARERPDGVWELDGL
MPVSELRARLGIRELPDEERGRYNTVAGLLMAVSGHLPEVGEHIDCAGWCFEIVALEGRR
IDRVLASPDPAAAPETD