Protein Info for GFF1936 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Erythronate-4-phosphate dehydrogenase (EC 1.1.1.290)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 378 PF00389: 2-Hacid_dh" amino acids 4 to 280 (277 residues), 63.2 bits, see alignment E=3.2e-21 PF02826: 2-Hacid_dh_C" amino acids 109 to 246 (138 residues), 103.7 bits, see alignment E=1.1e-33 PF11890: DUF3410" amino acids 289 to 369 (81 residues), 93.1 bits, see alignment E=1.2e-30

Best Hits

Swiss-Prot: 100% identical to PDXB_SALNS: Erythronate-4-phosphate dehydrogenase (pdxB) from Salmonella newport (strain SL254)

KEGG orthology group: K03473, erythronate-4-phosphate dehydrogenase [EC: 1.1.1.290] (inferred from 99% identity to sek:SSPA0458)

MetaCyc: 89% identical to erythronate-4-phosphate dehydrogenase (Escherichia coli K-12 substr. MG1655)
4-phosphoerythronate dehydrogenase. [EC: 1.1.1.290]

Predicted SEED Role

"Erythronate-4-phosphate dehydrogenase (EC 1.1.1.290)" in subsystem Pyridoxin (Vitamin B6) Biosynthesis (EC 1.1.1.290)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.290

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (378 amino acids)

>GFF1936 Erythronate-4-phosphate dehydrogenase (EC 1.1.1.290) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
VKILVDENMPYARELFSRLGEVKAVPGRPIPVEELNHADALMVRSVTKVNESLLSGTPIN
FVGTATAGTDHVDEAWLKQAGIGFSAAPGCNAIAVVEYVFSALLMLAERDGFSLRDRTIG
IVGVGNVGSRLQTRLEALGIRTLLCDPPRAARGDEGDFRTLDELVQEADVLTFHTPLYKD
GPYKTLHLADETLIRRLKPGAILINACRGPVVDNAALLARLNAGQPLSVVLDVWEGEPDL
NVALLEAVDIGTSHIAGYTLEGKARGTTQVFEAYSAFIGREQRVALETLLPAPEFGRITL
HGPLDQPTLKRLAHLVYDVRRDDAPLRKVAGIPGEFDKLRKNYLERREWSSLYVMCDDET
AAALLCKLGFNAVHHPAH